Very low levels of cholecystokinin octapeptide activate Na-pump in the cerebral cortex of CCK2 receptor-deficient mice

K. Roots; C. Kairane; T. Salum; S. Kõks; E. Karelson; E. Vasar; M. Zilmer

doi:10.1016/j.ijdevneu.2006.05.005

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Very low levels of cholecystokinin octapeptide activate Na-pump in the cerebral cortex of CCK2 receptor-deficient mice

Journal article

Peer reviewed

Very low levels of cholecystokinin octapeptide activate Na-pump in the cerebral cortex of CCK2 receptor-deficient mice

K. Roots, C. Kairane, T. Salum, S. Kõks, E. Karelson, E. Vasar and M. Zilmer

International Journal of Developmental Neuroscience, Vol.24(6), pp.395-400

2006

DOI: https://doi.org/10.1016/j.ijdevneu.2006.05.005

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Abstract

This study provides the first evidence that CCK-8 (0.01 pM to 0.1 mM) stimulates Na,K-ATPase in the cortical membranes of wild-type and CCK2 receptor-deficient mice. In each genotype, the maximal stimulation was about 40%. Homozygous mice revealed substantially lower EC50 (4 pM) than heterozygous (37 pM) or wild-type animals (682 pM). In homozygous CCK2 receptor-deficient mice, the expression of CCK1 receptor gene was 5-fold higher than in wild-type animals. CCK1 receptor antagonist devazepide counteracted effect of CCK-8 in all three genotypes, whereas CCK2 receptor antagonist L-365, 260 showed significant antagonism in wild-type and heterozygous mice. The cooperativity of Na,K-ATPase for Na+, but not for K+, was lost in homozygous mice. Altogether, very low concentrations of CCK-8 via CCK1 and CCK2 receptors stimulate Na,K-ATPase in the cerebral cortex. CCK2 receptor-deficiency leads to the altered functionality of Na,K-ATPase that might be compensated by CCK1 receptor mediated influence of CCK (and its agonists) on the enzyme.

Details

Title: Very low levels of cholecystokinin octapeptide activate Na-pump in the cerebral cortex of CCK2 receptor-deficient mice
Authors/Creators: K. Roots (Author/Creator)
C. Kairane (Author/Creator)
T. Salum (Author/Creator)
S. Kõks (Author/Creator)
E. Karelson (Author/Creator)
E. Vasar (Author/Creator)
M. Zilmer (Author/Creator)
Publication Details: International Journal of Developmental Neuroscience, Vol.24(6), pp.395-400
Publisher: Elsevier Ltd.
Identifiers: 991005542998307891
Copyright: © 2006 ISDN.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.195 Neuroendocrine & Intestinal Disorders; 1.195.1096 Gastrin/CCK Functions
Web Of Science research areas: Developmental Biology; Neurosciences
ESI research areas: Neuroscience & Behavior