Journal article
Virus-specific CD8+ T lymphocytes within the normal human liver
European Journal of Immunology, Vol.34(6), pp.1526-1531
2004
Abstract
The frequency and phenotype of human antiviral memory CD8+ T cells in blood are well studied, yet little is known about their distribution within tissues. Analysis of antiviral CD8+ T cell populations derived from a unique set of normal liver and blood samples identified a consistent population of virus-specific cells within the liver. In comparison to the circulating T cells, the liver-derived T cells were present at frequencies which were variably enriched compared to that in the blood, and showed significant differences with regard to the expression of CD45RA, CD45RO, CD95, CCR7, CD27 and CD28. The differences in these cell surface markers are consistent with a mature ‘effector memory’ phenotype of antigen-specific CD8+ T cells within the liver. An enrichment of an activated subset of NKT cells (Vα 24/Vβ 11) was also observed, a finding which may be relevant to the regulation of the antiviral populations.
Details
- Title
- Virus-specific CD8+ T lymphocytes within the normal human liver
- Authors/Creators
- S.M. Ward (Author/Creator) - Medawar Building for Pathogen ResearchJ.R. Jonsson (Author/Creator) - Princess Alexandra HospitalS. Sierro (Author/Creator) - Medawar Building for Pathogen ResearchA.D. Clouston (Author/Creator) - Princess Alexandra HospitalM. Lucas (Author/Creator) - Medawar Building for Pathogen ResearchA.L. Vargas (Author/Creator) - Medawar Building for Pathogen ResearchE.E. Powell (Author/Creator) - Princess Alexandra HospitalP. Klenerman (Author/Creator) - Medawar Building for Pathogen Research
- Publication Details
- European Journal of Immunology, Vol.34(6), pp.1526-1531
- Publisher
- John Wiley & Sons Ltd.
- Identifiers
- 991005544604707891
- Copyright
- © John Wiley & Sons, Inc.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.127 T Cell Regulation
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology