Journal article
Vitamin B12 as a carrier for the oral delivery of insulin
ChemMedChem, Vol.2(12), pp.1717-1721
2007
Abstract
The noninvasive delivery of insulin continues to be a major goal for the treatment of diabetes mellitus. Oral-enteric administration would make insulin delivery easier and more effective, as higher patient compliance and improved glycemic control are likely; yet the oral-enteric pathway has been unfeasible owing to insulin's susceptibility to proteolytic degradation and inefficient enteric uptake. Herein we show that a noninvasive oral delivery route for insulin is possible through the vitamin B12 uptake pathway. In diabetic rat models, insulin-B12 conjugates can significantly lower blood glucose levels when administered orally.
Details
- Title
- Vitamin B12 as a carrier for the oral delivery of insulin
- Authors/Creators
- A.K. Petrus (Author/Creator) - Syracuse UniversityA.R. Vortherms (Author/Creator) - Syracuse UniversityT.J. Fairchild (Author/Creator) - Syracuse UniversityR.P. Doyle (Author/Creator) - Syracuse University
- Publication Details
- ChemMedChem, Vol.2(12), pp.1717-1721
- Publisher
- John Wiley and Sons Ltd
- Identifiers
- 991005544078507891
- Copyright
- © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 2 Chemistry
- 2.276 Metalloenzymes
- 2.276.1947 Radical Enzymes
- Web Of Science research areas
- Chemistry, Medicinal
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology