Journal article
Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin
Journal of Physiology and Biochemistry, Vol.67(3), pp.381-390
2011
Abstract
Valproic acid (VLP) is a widely used anticonvulsant and mood-stabilizing drug that relieves the endoplasmic reticulum (ER) stress response, a pathogenetic process related to diabetes. The aim of the present study was to evaluate whether acute valproic acid is able to interfere with glucose intolerance in two different diabetes models: The first model was a Wfs1 mutant mouse with an elevated ER stress response and the second model a streptozocin-induced diabetic mouse. VLP (300 mg/kg, i.p.) was administered to Wfs1 knockout (KO) mice and glucose tolerance test was performed 15 min later. VLP did not have an effect on the course of the glucose tolerance test in wild-type mice, while it did normalize the glucose intolerance in Wfs1 knockout mice. Acute valproic acid also lowered the blood glucose levels in streptozocin-treated mice and potentiated the effect of insulin in these mice. Thus, acute valproic acid is effective in lowering blood glucose levels possibly by potentiating insulin action in both Wfs1 KO mice and in streptozocin-induced type 1 diabetic mice.
Details
- Title
- Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin
- Authors/Creators
- A. Terasmaa (Author/Creator) - University of TartuU. Soomets (Author/Creator) - University of TartuJ. Oflijan (Author/Creator) - University of TartuM. Punapart (Author/Creator) - University of TartuM. Hansen (Author/Creator) - University of TartuV. Matto (Author/Creator) - University of TartuK. Ehrlich (Author/Creator) - University of TartuA. Must (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Journal of Physiology and Biochemistry, Vol.67(3), pp.381-390
- Publisher
- Springer Netherlands
- Identifiers
- 991005546346307891
- Copyright
- © University of Navarra 2011
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis
- 1.25.1406 Unfolded Protein Response
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Physiology
- ESI research areas
- Biology & Biochemistry