What are the optimal transcranial direct current stimulation parameters and design elements to modulate corticospinal excitability? A systematic review and longitudinal meta-analysis

Liam C Tapsell; Matheus D Pinto; Ann-Maree Vallence; Casey Whife; Maria Luciana Perez Armendariz; Shaswat Senger; Jack Andringa-Bate; Dana Hince; Myles C Murphy

doi:10.1186/s42466-025-00449-1

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What are the optimal transcranial direct current stimulation parameters and design elements to modulate corticospinal excitability? A systematic review and longitudinal meta-analysis

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What are the optimal transcranial direct current stimulation parameters and design elements to modulate corticospinal excitability? A systematic review and longitudinal meta-analysis

Liam C Tapsell, Matheus D Pinto, Ann-Maree Vallence, Casey Whife, Maria Luciana Perez Armendariz, Shaswat Senger, Jack Andringa-Bate, Dana Hince and Myles C Murphy

Neurological research and practice, Vol.7(1), 86

2025

DOI: https://doi.org/10.1186/s42466-025-00449-1

PMID: 41219988

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Abstract

Facilitation

Neural plasticity

tDCS

Motor cortex

Cortical excitability

Electrical brain stimulation

Stimulation parameters

Inhibition

Background Corticospinal excitability, measured by motor-evoked potentials (MEPs), is often impaired in neurological and musculoskeletal conditions. Transcranial direct current stimulation (tDCS) can modulate cortical excitability and improve clinical outcomes, yet inconsistencies in parameter settings complicate identification of optimal protocols. Objective Our primary objective was to examine the effects of: (i) stimulation polarity, (ii) duration, (iii) intensity, (iv) frequency, (v) electrode montage, and (vi) electrode design (size/shape) on MEP size. Methods Nine databases were searched from inception to 24th November 2023. We identified 84 individual cohorts (1,709 participants) and assessed time-dependent effects of each parameter on M1 MEP-to-baseline ratio in healthy and clinical populations using multi-level longitudinal meta-analysis. Results Anodal tDCS increased MEP size, with effects lasting up to 120 min post-stimulation. Consistent effects were observed with anodal tDCS durations ≥ 20 min and intensities ≥ 1.5 mA. Despite cohorts being matched, cathodal tDCS reduced MEP size for approximately 15 min post-stimulation, with significant effects at durations ≥ 9 min, intensity effects were inconclusive. Electrode montage and electrode size/shape influenced MEP, with greatest effect for electrodes over both the primary motor cortex and the dorsolateral pre-frontal cortex or over the cerebellar region, using 4 cm2 ring and 35 cm2 rectangular electrodes. Conclusion tDCS effects on corticospinal excitability are parameter dependent. Anodal tDCS tends to facilitate excitability, whereas cathodal tDCS tends to inhibit excitability (depending on stimulation parameters). Specific durations, intensities, electrode placements and designs will ensure effectiveness and optimise safety. Findings support a parameter-specific approach to guide tailored neuromodulation interventions to enhance motor cortex rehabilitation outcomes.

Details

Title: What are the optimal transcranial direct current stimulation parameters and design elements to modulate corticospinal excitability? A systematic review and longitudinal meta-analysis
Authors/Creators: Liam C Tapsell - Edith Cowan University
Matheus D Pinto - Edith Cowan University
Ann-Maree Vallence - Murdoch University
Casey Whife - Edith Cowan University
Maria Luciana Perez Armendariz - Nutrition and Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia
Shaswat Senger - University of Western Australia
Jack Andringa-Bate - La Trobe University
Dana Hince - The University of Notre Dame Australia
Myles C Murphy - The University of Notre Dame Australia
Publication Details: Neurological research and practice, Vol.7(1), 86
Publisher: Springer Nature
Grant note: IF2022-23/5 / Department of Health, Government of Western Australia RPG035-2023 / Raine Medical Research Foundation
Identifiers: 991005830248107891
Murdoch Affiliation: School of Psychology; Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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