Journal article
What can quantitative gait analysis tell us about dementia and its subtypes? A structured review
Journal of Alzheimer's Disease, Vol.60(4), pp.1295-1312
2017
Abstract
Distinguishing dementia subtypes can be difficult due to similarities in clinical presentation. There is increasing interest in discrete gait characteristics as markers to aid diagnostic algorithms in dementia. This structured review explores the differences in quantitative gait characteristics between dementia and healthy controls, and between four dementia subtypes under single-task conditions: Alzheimer’s disease (AD), dementia with Lewy bodies and Parkinson’s disease dementia, and vascular dementia. Twenty-six papers out of an initial 5,211 were reviewed and interpreted using a validated model of gait. Dementia was associated with gait characteristics grouped by slower pace, impaired rhythm, and increased variability compared to normal aging. Only four studies compared two or more dementia subtypes. People with AD are less impaired in pace, rhythm, and variability domains of gait compared to non-AD dementias. Results demonstrate the potential of gait as a clinical marker to discriminate between dementia subtypes. Larger studies using a more comprehensive battery of gait characteristics and better characterized dementia sub-types are required.
Details
- Title
- What can quantitative gait analysis tell us about dementia and its subtypes? A structured review
- Authors/Creators
- R. McArdle (Author/Creator)R. Morris (Author/Creator) - Newcastle UniversityJ. Wilson (Author/Creator) - Newcastle UniversityB. Galna (Author/Creator) - Newcastle UniversityA.J. Thomas (Author/Creator) - Newcastle UniversityL. Rochester (Author/Creator) - Newcastle University
- Publication Details
- Journal of Alzheimer's Disease, Vol.60(4), pp.1295-1312
- Publisher
- IOS Press
- Identifiers
- 991005542794907891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.263 Gait and Balance
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior