Journal article
What is the identity of fibroblast-pneumocyte factor?
Pediatric Research, Vol.80(6), pp.768-776
2016
Abstract
Glucocorticoid induction of pulmonary surfactant involves a mesenchyme-derived protein first characterized in 1978 by Smith and termed fibroblast-pneumocyte factor (FPF). Despite a number of agents having been postulated as being FPF, its identity has remained obscure. In the past decade, three strong candidates for FPF have arisen. This review examines the evidence that keratinocyte growth factor (KGF), leptin or neuregulin-1β (NRG-1β) act as FPF or components of it. As with FPF production, glucocorticoids enhance the concentration of each of these agents in fibroblast-conditioned media. Moreover, each stimulates the synthesis of surfactant-associated phospholipids and proteins in type II pneumocytes. Further, some have unique activities, for example, KGF also minimizes lung injury through enhanced epithelial cell proliferation and NRG-1β enhances surfactant phospholipid secretion and β-adrenergic receptor activity in type II cells. However, even though these agents have attributes in common with FPF, it is inappropriate to specify any one of these agents as FPF. Rather, it appears that each contributes to separate mesenchymal-epithelial signaling mechanisms involved in different aspects of lung development. Given that the production of pulmonary surfactant is essential for postnatal survival, it is reasonable to suggest that several mechanisms independently regulate surfactant synthesis.
Details
- Title
- What is the identity of fibroblast-pneumocyte factor?
- Authors/Creators
- G. King (Author/Creator)M.E. Smith (Author/Creator)M.H. Cake (Author/Creator)H.C. Nielsen (Author/Creator)
- Publication Details
- Pediatric Research, Vol.80(6), pp.768-776
- Publisher
- Lippincott Williams & Wilkins Ltd
- Identifiers
- 991005543124207891
- Copyright
- © 2016 International Pediatric Research Foundation, Inc.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
76 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.1057 Pulmonary Surfactant
- Web Of Science research areas
- Pediatrics
- ESI research areas
- Clinical Medicine