Journal article
What to do ... When the treatment does not work: Polymyositis
Postgraduate Medical Journal, Vol.84(993), pp.382-384
2008
Abstract
Although patients with polymyositis or dermatomyositis may respond to treatment with corticosteroids alone, in many cases a combination of steroids and an immunosuppressive agent is required to achieve satisfactory disease control and remission.1 However, about 20–30% of patients with polymyositis, and a similar proportion of cases of dermatomyositis and overlap syndromes, have persisting weakness and raised serum creatine kinase (CK) activity, or continue to deteriorate. In such cases it is necessary to review the clinical and muscle biopsy findings on which the diagnosis of an inflammatory myopathy had been based, and whether the treatment administered had been appropriate, and consider other treatment options. In addition, if they have not already been done, investigations should be performed to exclude an underlying malignancy and other contributory causes of muscle weakness and raised serum CK activity, such as thyroid and other endocrine conditions and drug-induced disorders...
Details
- Title
- What to do ... When the treatment does not work: Polymyositis
- Authors/Creators
- F.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
- Publication Details
- Postgraduate Medical Journal, Vol.84(993), pp.382-384
- Publisher
- BMJ Publishing Group
- Identifiers
- 991005542079707891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Clinical Medicine