Whole genome association study of rheumatoid arthritis using 27 039 microsatellites

G. Tamiya; M. Shinya; T. Imanishi; T. Ikuta; S. Makino; K. Okamoto; K. Furugaki; T. Matsumoto; S. Mano; S. Ando; Y. Nozaki; W. Yukawa; R. Nakashige; D. Yamaguchi; H. Ishibashi; M. Yonekura; Y. Nakami; S. Takayama; T. Endo; T. Saruwatari; M. Yagura; Y. Yoshikawa; K. Fujimoto; A. Oka; S. Chiku; S.E.V. Linsen; M.J. Giphart; J.K. Kulski; T. Fukazawa; H. Hashimoto; M. Kimura; Y. Hoshina; Y. Suzuki; T. Hotta; J. Mochida; T. Minezaki; K. Komai; S. Shiozawa; A. Taniguchi; H. Yamanaka; N. Kamatani; T. Gojobori; S. Bahram; H. Inoko

doi:10.1093/hmg/ddi234

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Whole genome association study of rheumatoid arthritis using 27 039 microsatellites

Journal article

Peer reviewed

Whole genome association study of rheumatoid arthritis using 27 039 microsatellites

G. Tamiya, M. Shinya, T. Imanishi, T. Ikuta, S. Makino, K. Okamoto, K. Furugaki, T. Matsumoto, S. Mano, S. Ando, …

Human Molecular Genetics, Vol.14(16), pp.2305-2321

2005

DOI: https://doi.org/10.1093/hmg/ddi234

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Abstract

A major goal of current human genome-wide studies is to identify the genetic basis of complex disorders. However, the availability of an unbiased, reliable, cost efficient and comprehensive methodology to analyze the entire genome for complex disease association is still largely lacking or problematic. Therefore, we have developed a practical and efficient strategy for whole genome association studies of complex diseases by charting the human genome at 100 kb intervals using a collection of 27 039 microsatellites and the DNA pooling method in three successive genomic screens of independent case-control populations. The final step in our methodology consists of fine mapping of the candidate susceptible DNA regions by single nucleotide polymorphisms (SNPs) analysis. This approach was validated upon application to rheumatoid arthritis, a destructive joint disease affecting up to 1% of the population. A total of 47 candidate regions were identified. The top seven loci, withstanding the most stringent statistical tests, were dissected down to individual genes and/or SNPs on four chromosomes, including the previously known 6p21.3-encoded Major Histocompatibility Complex gene, HLA-DRB1. Hence, microsatellite-based genome-wide association analysis complemented by end stage SNP typing provides a new tool for genetic dissection of multifactorial pathologies including common diseases.

Details

Title: Whole genome association study of rheumatoid arthritis using 27 039 microsatellites
Authors/Creators: G. Tamiya (Author/Creator) - National Institute of Advanced Industrial Science and Technology
M. Shinya (Author/Creator) - National Institute of Advanced Industrial Science and Technology
T. Imanishi (Author/Creator) - National Institute of Advanced Industrial Science and Technology
T. Ikuta (Author/Creator) - National Institute of Advanced Industrial Science and Technology
S. Makino (Author/Creator) - Tokai University
K. Okamoto (Author/Creator) - National Institute of Advanced Industrial Science and Technology
K. Furugaki (Author/Creator) - National Institute of Advanced Industrial Science and Technology
T. Matsumoto (Author/Creator) - Hitachi (Japan)
S. Mano (Author/Creator) - Tokai University
S. Ando (Author/Creator) - Tokai University
Y. Nozaki (Author/Creator) - Hitachi (Japan)
W. Yukawa (Author/Creator) - National Institute of Advanced Industrial Science and Technology
R. Nakashige (Author/Creator) - Hitachi (Japan)
D. Yamaguchi (Author/Creator) - Hitachi (Japan)
H. Ishibashi (Author/Creator) - National Institute of Advanced Industrial Science and Technology
M. Yonekura (Author/Creator) - National Institute of Advanced Industrial Science and Technology
Y. Nakami (Author/Creator) - National Institute of Advanced Industrial Science and Technology
S. Takayama (Author/Creator) - Mitsui & Co.
T. Endo (Author/Creator) - Tokai University
T. Saruwatari (Author/Creator) - National Institute of Advanced Industrial Science and Technology
M. Yagura (Author/Creator) - Tokai University
Y. Yoshikawa (Author/Creator) - Nisshinbo Holdings (Japan)
K. Fujimoto (Author/Creator) - Tokai University
A. Oka (Author/Creator) - Tokai University
S. Chiku (Author/Creator) - Fujifilm (Japan)
S.E.V. Linsen (Author/Creator) - Leiden University
M.J. Giphart (Author/Creator) - Leiden University
J.K. Kulski (Author/Creator) - Murdoch University
T. Fukazawa (Author/Creator) - Juntendo University
H. Hashimoto (Author/Creator) - Juntendo University
M. Kimura (Author/Creator) - Tokai University
Y. Hoshina (Author/Creator) - Tokai University
Y. Suzuki (Author/Creator) - Tokai University
T. Hotta (Author/Creator) - Tokai University
J. Mochida (Author/Creator) - Tokai University
T. Minezaki (Author/Creator) - Tokai University
K. Komai (Author/Creator) - Kobe University
S. Shiozawa (Author/Creator) - Kobe University
A. Taniguchi (Author/Creator) - Tokyo Women's Medical University
H. Yamanaka (Author/Creator) - Tokyo Women's Medical University
N. Kamatani (Author/Creator) - National Institute of Advanced Industrial Science and Technology
T. Gojobori (Author/Creator) - National Institute of Advanced Industrial Science and Technology
S. Bahram (Author/Creator) - Institut National de la Sante et de la Recherche Medicale
H. Inoko (Author/Creator) - National Institute of Advanced Industrial Science and Technology
Publication Details: Human Molecular Genetics, Vol.14(16), pp.2305-2321
Publisher: Oxford University Press
Identifiers: 991005545546007891
Copyright: © The Author 2005
Murdoch Affiliation: School of Information Technology
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.455 Genome-Wide Association Studies
Web Of Science research areas: Biochemistry & Molecular Biology; Genetics & Heredity
ESI research areas: Molecular Biology & Genetics