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CC BY V4.0, Open Access
Journal article
Wnt/?-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis
Journal of renal and hepatic disorders, Vol.2(1), pp.1-9
2018
Abstract
Chronic liver diseases (CLDs) are increasing in prevalence and their end-stage complications, namely, cirrhosis, liver failure and hepatocellular carcinoma represent major global challenges. The most common initiators of progressive CLD are viral hepatitis and long-term alcohol abuse as well as steatosis and steatohepatitis. Irrespective of the underlying aetiology, a common feature of CLD is the formation of hepatic ductular reactions, involving the proliferation of liver progenitor cells (LPCs) and their signalling to fibrosis-driving hepatic stellate cells. The Wnt/?-catenin pathway has been found to regulate development, stemness and differentiation, and alterations in its activity have been associated with tumour development. Recent data highlight the role of Wnt/?-catenin signalling in hepatic metabolism, steatosis and cancer, and suggest targeting of this pathway as a promising molecular strategy to potentially inhibit CLD progression and hepatocarcinogenesis.
Details
- Title
- Wnt/?-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis
- Authors/Creators
- Gayatri D Shirolkar - Curtin UniversitySara Pasic - Curtin UniversityJully Gogoi TiwariManoj K Bhat - Savitribai Phule Pune UniversityJohn K Olynyk - Edith Cowan UniversityArun Dharmarajan - Curtin UniversityJanina EE Tirnitz-Parker
- Publication Details
- Journal of renal and hepatic disorders, Vol.2(1), pp.1-9
- Publisher
- Codon Publications
- Identifiers
- 991005703766907891
- Copyright
- © 2018 Shirolkar GD et al.
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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