Journal article
YAPping about and not forgetting TAZ
FEBS Letters, Vol.593(3), pp.253-276
2019
Abstract
The Hippo pathway has emerged as a major eukaryotic signalling pathway and is increasingly the subject of intense interest, as are the key effectors of canonical Hippo signalling, YES‐associated protein (YAP) and TAZ. The Hippo pathway has key roles in diverse biological processes, including network signalling regulation, development, organ growth, tissue repair and regeneration, cancer, stem cell regulation and mechanotransduction. YAP and TAZ are multidomain proteins and function as transcriptional coactivators of key genes to evoke their biological effects. YAP and TAZ interact with numerous partners and their activities are controlled by a complex set of processes. This review provides an overview of Hippo signalling and its role in growth. In particular, the functional domains of YAP and TAZ and the complex mechanisms that regulate their protein stability and activity are discussed. Notably, the similarities and key differences are highlighted between the two paralogues including which partner proteins interact with which functional domains to regulate their activity.
Details
- Title
- YAPping about and not forgetting TAZ
- Authors/Creators
- B.A. Callus (Author/Creator)M.L. Finch-Edmondson (Author/Creator)S. Fletcher (Author/Creator)S.D. Wilton (Author/Creator)
- Publication Details
- FEBS Letters, Vol.593(3), pp.253-276
- Publisher
- Elsevier
- Identifiers
- 991005541133507891
- Copyright
- © 2018 The Authors.
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.108 Molecular & Cell Biology - Cancer & Development
- 1.108.2215 Hippo Pathway
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- ESI research areas
- Biology & Biochemistry