Journal article
Zinc oxide nanoparticle caused plasma metabolomic perturbations correlate with hepatic steatosis
Frontiers in Pharmacology, Vol.9, Art. 00057
2018
Abstract
Zinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption, are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs. However, they have also been found to adversely affect organisms; previously we found that ZnO NPs disrupt pubertal ovarian development, inhibit embryonic development by upsetting γ-H2AX and NF-κB pathways, and even disturb skin stem cells. Non-targeted metabolomic analysis of biological organisms has been suggested as an unbiased tool for the investigation of perturbations in response to NPs and their underlying mechanisms. Although metabolomics has been used in nanotoxicological studies, very few reports have used it to investigate the effects of ZnO NPs exposure. In the current investigation, through a metabolomics-based approach, we discovered that ZnO NPs caused changes in plasma metabolites involved in anti-oxidative mechanisms, energy metabolism, and lipid metabolism in hen livers. These results are in line with earlier findings that ZnO NPs perturb the tricarboxylic acid cycle and in turn result in the use of alternative energy sources. We also found that ZnO NPs disturbed lipid metabolism in the liver and consequently impacted blood lipid balance. Changes in plasma metabolomes were correlated with hepatic steatosis.
Details
- Title
- Zinc oxide nanoparticle caused plasma metabolomic perturbations correlate with hepatic steatosis
- Authors/Creators
- W. Zhang (Author/Creator) - Qingdao Agricultural UniversityY. Zhao (Author/Creator) - Qingdao Agricultural UniversityF. Li (Author/Creator) - Qingdao Institute of Bioenergy and Bioprocess TechnologyL. Li (Author/Creator) - Qingdao Agricultural UniversityY. Feng (Author/Creator) - Qingdao Agricultural UniversityL. Min (Author/Creator) - Qingdao Agricultural UniversityD. Ma (Author/Creator) - Qingdao Agricultural UniversityS. Yu (Author/Creator) - Qingdao Agricultural UniversityJ. Liu (Author/Creator) - Qingdao Agricultural UniversityH. Zhang (Author/Creator) - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.T. Shi (Author/Creator) - Shandong Academy of Agricultural SciencesF. Li (Author/Creator) - Qingdao Institute of Bioenergy and Bioprocess TechnologyW. Shen (Author/Creator) - Qingdao Agricultural University
- Publication Details
- Frontiers in Pharmacology, Vol.9, Art. 00057
- Publisher
- Frontiers Media S.A.
- Identifiers
- 991005545113607891
- Copyright
- © 2018 Zhang et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 2 Chemistry
- 2.67 Nanoparticles
- 2.67.231 Nanotoxicology
- Web Of Science research areas
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology