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Open Access CC BY V4.0
Letter/Communication
Limosilactobacillus reuteri enhances ovarian function and female fertility
iMeta, Vol.5(4), e70164
2026
PMID: 42564919
Abstract
Limosilactobacillus reuteri Y15 (LRY15)‐derived polyunsaturated fatty acids (PUFAs) restore follicular cell‐cell junctions and fertility. LRY15, isolated from the intestine of alginate oligosaccharides (AOS)‐dosed mice, improves ovarian function and fertility in cisplatin‐induced subfertile mice. LRY15 produces PUFAs, whereas deletion of holo‐acyl carrier protein synthase (AcpS) in LRY15 reduces PUFA synthesis and weakens its protective effects. Docosahexaenoic acid (DHA) supplementation recapitulates LRY15‐mediated improvements in follicle and embryo development. Stereo‐seq analysis reveals that LRY15 restores ovarian cell‐cell junctions, suggesting junction remodeling as an important cellular process associated with LRY15 treatment. The Fads2‐deficient mouse model further validates that LRY15‐derived PUFAs restore follicular junction integrity and improve fertility.
Details
- Title
- Limosilactobacillus reuteri enhances ovarian function and female fertility
- Authors/Creators
- Yongsheng Hao - Chinese Academy of Agricultural SciencesYukang Li - Qingdao Agricultural UniversityShen Li - Chinese Academy of Agricultural SciencesJuanli Huo - Shanxi Agricultural UniversityNinghang You - Chinese Academy of Agricultural SciencesLei Li - Shanxi Agricultural UniversityYue Jiang - Chinese Academy of Agricultural SciencesWeidong Zhang - Institute of Animal SciencesHuakai Wei - Chinese Academy of Agricultural SciencesQingyuan Sun - Guangdong Provincial People's HospitalYunwei Pang - Chinese Academy of Agricultural SciencesXunsi Qin - Peking UniversityTao Tu - Chinese Academy of Agricultural SciencesHuoqing Huang - Chinese Academy of Agricultural SciencesJian Tian - Chinese Academy of Agricultural SciencesPengfei Zhang - Murdoch UniversityYaru Wang - Chinese Academy of Agricultural SciencesXinxin Xu - Chinese Academy of Agricultural SciencesBin Yao - Chinese Academy of Agricultural SciencesWei Shen - Qingdao Agricultural UniversityXing Qin - Peking UniversityHuiying Luo - Chinese Academy of Agricultural SciencesYong Zhao - Institute of Animal Sciences
- Publication Details
- iMeta, Vol.5(4), e70164
- Publisher
- John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
- Identifiers
- 991005909766207891
- Copyright
- © 2026 The Author(s).
- Murdoch Affiliation
- College of Environmental and Life Sciences
- Language
- English
- Resource Type
- Letter/Communication
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