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Enzymatic incorporation of LNA nucleotides
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Enzymatic incorporation of LNA nucleotides

J. Wengel, B. Vester and R.N. Veedu
Patent No: WO/2009/039862
RIBOTASK APS
2009
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Abstract

The present invention relates to oligonucleotides comprising LNA units and enzymatic methods of synthesizing such oligonucleotides. Oligonucleotide comprising LNA units have various characteristics, e.g. improved biostability and increased > affinity for complementary oligonucleotides. The methods may be part of detection reactions, polymerase chain reaction, RNA transcription or in vitro evolution processes such as SELEX.

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