Patent
INFECTION DIAGNOSIS AND CHARACTERIZATION USING DIFFUSION AND RELAXATION EDITED PROTON NMR SPECTROSCOPY
BRUKER BIOSPIN GMBH/MUrdoch UNiversity
28/07/2022
Abstract
1H-NMR spectroscopic molecular markers are provided for identifying medical risk signatures such as SARS-CoV-2 infection, acute inflammation, or a cardiovascular risk condition. The markers use a combination of NMR intensity signals, including a Glyc signal from at least one N-acetyl (-NCOCH3) glycoprotein and an SPC signal from a choline head group (+N-(CH3)3) of a supramolecular phospholipids cluster (SPC) present in HDL and LDL lipoprotein subfractions. The Glyc signal is in a chemical shift region from ẟ = 2.00 ppm to ẟ = 2.20 ppm, and includes signals GlycA (2.00 ppm to 2.09 ppm) and GlycB (2.09 ppm to 2.2 ppm). The SPC signal is in a chemical shift region from ẟ = 3.20 ppm to ẟ = 3.30 ppm, and includes signals SPC1 (3.2 ppm to 3.235) ppm, SPC2 (3.235 ppm to 3.26 ppm), and SPC3 (3.26 ppm to 3.3 ppm). A system for identifying the markers is also provided.
Details
- Title
- INFECTION DIAGNOSIS AND CHARACTERIZATION USING DIFFUSION AND RELAXATION EDITED PROTON NMR SPECTROSCOPY
- Authors/Creators
- Jeremy K NicholsonElaine HolmesSamantha LodgeJulien WistWolfgang BermelTony ReinspergerPhilipp Nitschke
- Publisher
- BRUKER BIOSPIN GMBH/MUrdoch UNiversity
- Identifiers
- 991005598967107891
- Murdoch Affiliation
- Health Futures Institute; Centre for Computational and Systems Medicine
- Language
- English; French
- Resource Type
- Patent
- Patent
- WO2022157729
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