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CC BY-NC-ND V4.0, Open Access
Preprint
Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity
bioRxiv
Cold Spring Harbor Laboratory
2020
Abstract
Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective approaches to contain the pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome sequences, we provided direct genetic evidence that SARS-CoV-2 has a much lower mutation rate than SARS. Minimum Evolution phylogeny analysis revealed the putative original status of SARS-CoV-2 and the early-stage spread history. The discrepant phylogenies for the spike protein and its receptor binding domain proved a previously reported structural rearrangement prior to the emergence of SARS-CoV-2. Despite that we found the spike glycoprotein of SARS-CoV-2 is particularly more conserved, we identified a receptor binding domain mutation that leads to weaker ACE2 binding capability based on in silico simulation, which concerns a SARS-CoV-2 sample collected on 27th January 2020 from India. This represents the first report of a significant SARS-CoV-2 mutant, and requires attention from researchers working on vaccine development around the world.
Details
- Title
- Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity
- Authors/Creators
- Yong JiaG. ShenS. NguyenY. ZhangK. HuangH. HoW. HorC. YangJ. B. BruningChengdao Li - Murdoch University, Centre for Crop and Food InnovationW. Wang
- Publication Details
- bioRxiv
- Publisher
- Cold Spring Harbor Laboratory
- Identifiers
- 991005655369707891
- Copyright
- The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
- Murdoch Affiliation
- Murdoch University; Centre for Crop and Food Innovation
- Resource Type
- Preprint
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