Files and links (1)
Open Access CC BY V4.0
Preprint
Determining the utility of ultrafast nonlinear contrast enhanced and super resolution ultrasound for imaging microcirculation in the human small intestine
ArXiv.org
Cornell University
2025
Abstract
The regulation of intestinal blood flow is critical to gastrointestinal function. Imaging the intestinal mucosal micro-circulation in vivo has the potential to provide new insight into the gut physiology and pathophysiology. We aimed to determine whether ultrafast contrast enhanced ultrasound (CEUS) and super-resolution ultrasound localisation microscopy (SRUS/ULM) could be a useful tool for imaging the small intestine microcirculation in vivo non-invasively and for detecting changes in blood flow in the duodenum. Ultrafast CEUS and SRUS/ULM were used to image the small intestinal microcirculation in a cohort of 20 healthy volunteers (BMI<25). Participants were imaged while conscious and either having been fasted, or following ingestion of a liquid meal or water control, or under acute stress. For the first time we have performed ultrafast CEUS and ULM on the human small intestine, providing unprecedented resolution images of the intestinal microcirculation. We evaluated flow speed inside small vessels in healthy volunteers (2.78 +/- 0.05 mm/s, mean +/- SEM) and quantified changes in the perfusion of this microcirculation in response to nutrient ingestion. Perfusion of the microvasculature of the intestinal mucosa significantly increased post-prandially (36.2% +/- 12.2%, mean +/- SEM, p<0.05). The feasibility of 3D SRUS/ULM was also demonstrated. This study demonstrates the potential utility of ultrafast CEUS for assessing perfusion and detecting changes in blood flow in the duodenum. SRUS/ULM also proved a useful tool to image the microvascular blood flow in vivo non-invasively and to evaluate blood speed inside the microvasculature of the human small intestine.
Details
- Title
- Determining the utility of ultrafast nonlinear contrast enhanced and super resolution ultrasound for imaging microcirculation in the human small intestine
- Authors/Creators
- Clotilde ViéMartina TashkovaJames BurnMatthieu ToulemondeJipeng YanJingwen ZhuCameron A. B SmithBiao HuangSu YanKevin G MurphyGary FrostMeng-Xing Tang
- Publication Details
- ArXiv.org
- Publisher
- Cornell University
- Identifiers
- 991005884850207891
- Murdoch Affiliation
- Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Preprint
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: SDGs in the Output
Metrics
1 Record Views