A Comparative Study of Polysomnography-Derived Sleep Disturbance in People Living With Multiple Sclerosis Compared to Matched Controls From the General Population

Amy C Reynolds; Emma Thomas; Yohannes Adama Melaku; Hanna A Hensen; Arun V Krishnan; Simon C Gandevia; Stephen R Lord; Peter R Eastwood; Danny J Eckert

doi:10.1111/jsr.70075

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A Comparative Study of Polysomnography-Derived Sleep Disturbance in People Living With Multiple Sclerosis Compared to Matched Controls From the General Population

Journal article

Open access

Peer reviewed

A Comparative Study of Polysomnography-Derived Sleep Disturbance in People Living With Multiple Sclerosis Compared to Matched Controls From the General Population

Amy C Reynolds, Emma Thomas, Yohannes Adama Melaku, Hanna A Hensen, Arun V Krishnan, Simon C Gandevia, Stephen R Lord, Peter R Eastwood and Danny J Eckert

Journal of sleep research, e70075

2025

DOI: https://doi.org/10.1111/jsr.70075

PMID: 40290082

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Abstract

obstructive sleep apnea

polysomnography

chronic disease

multiple sclerosis

periodic limb movement disorder

sleep wake disorders

Sleep structure and sleep disorders were compared between people with multiple sclerosis (MS; n = 39) and age, sex, and BMI-matched members of the general population (n = 39) using overnight polysomnography (PSG). Compared to population controls, people with MS had a higher prevalence of periodic limb movement disorder (PLMD; 59% vs. 18%, p < 0.001) and PLM-related arousals (PLMI: 21.1 vs. 0.8, p < 0.001); as well as longer sleep duration (402.9 [59.8] vs. 370.4 [54.0] min, p = 0.014), longer median sleep latency (12.4 min) and a reduced proportion of total sleep time in stage N1 sleep (8.5% vs. 14.8%, p < 0.001) and more time in N2 sleep (54.4% vs. 48.0%, p < 0.001). Sleep architecture appeared to differ for people with MS, even in the context of no recent exacerbations or relapse. Managing periodic leg movements during sleep may help improve sleep quality in people with MS.

Details

Title: A Comparative Study of Polysomnography-Derived Sleep Disturbance in People Living With Multiple Sclerosis Compared to Matched Controls From the General Population
Authors/Creators: Amy C Reynolds - Adelaide Institute for Sleep Health
Emma Thomas - Adelaide Institute for Sleep Health
Yohannes Adama Melaku - Adelaide Institute for Sleep Health
Hanna A Hensen - Neuroscience Research Australia
Arun V Krishnan - UNSW Sydney
Simon C Gandevia - Neuroscience Research Australia
Stephen R Lord - Neuroscience Research Australia
Peter R Eastwood - Murdoch University
Danny J Eckert - Adelaide Institute for Sleep Health
Publication Details: Journal of sleep research, e70075
Publisher: John Wiley & Sons Ltd on behalf of European Sleep Research Society.
Number of pages: 6
Identifiers: 991005773249007891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.137 Sleep Science & Circadian Systems; 1.137.2136 Restless Legs Syndrome
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior