A systems biology approach to better understand human tick-borne diseases

Wenna Lee; Amanda D. Barbosa; Peter J. Irwin; Andrew Currie; Tobias R. Kollmann; Miles Beaman; Amy H. Lee; Charlotte L. Oskam

doi:10.1016/j.pt.2022.10.006

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A systems biology approach to better understand human tick-borne diseases

Journal article

Peer reviewed

A systems biology approach to better understand human tick-borne diseases

Wenna Lee, Amanda D. Barbosa, Peter J. Irwin, Andrew Currie, Tobias R. Kollmann, Miles Beaman, Amy H. Lee and Charlotte L. Oskam

Trends in parasitology, Vol.39(1), pp.53-69

01/2023

DOI: https://doi.org/10.1016/j.pt.2022.10.006

PMID: 36400674

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Abstract

emerging diseases

multi-dimensional

network biology

systems biology

tick-borne diseases

tick–host–pathogen

Tick-borne diseases (TBDs) are a growing global health concern. Despite extensive studies, ill-defined tick-associated pathologies remain with unknown aetiologies. Human immunological responses after tick bite, and inter-individual variations of immune-response phenotypes, are not well characterised. Current reductive experimental methodologies limit our understanding of more complex tick-associated illness, which results from the interactions between the host, tick, and microbes. An unbiased, systems-level integration of clinical metadata and biological host data - obtained via transcriptomics, proteomics, and metabolomics - offers to drive the data-informed generation of testable hypotheses in TBDs. Advanced computational tools have rendered meaningful analysis of such large data sets feasible. This review highlights the advantages of integrative system biology approaches as essential for understanding the complex pathobiology of TBDs.

Details

Title: A systems biology approach to better understand human tick-borne diseases
Authors/Creators: Wenna Lee - Centre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Perth, WA, Australia
Amanda D. Barbosa - Centre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Perth, WA, Australia
Peter J. Irwin - Centre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Perth, WA, Australia
Andrew Currie - Murdoch University
Tobias R. Kollmann - The Kids Research Institute Australia
Miles Beaman - Faculty of Health and Medical Sciences, Pathology & Laboratory Medicine, University of Western Australia, Perth, WA, Australia
Amy H. Lee - Simon Fraser University
Charlotte L. Oskam - Centre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Perth, WA, Australia
Publication Details: Trends in parasitology, Vol.39(1), pp.53-69
Publisher: Elsevier Ltd
Identifiers: 991005578638507891
Murdoch Affiliation: College of Environmental and Life Sciences; Harry Butler Institute; Centre for Molecular Medicine and Innovative Therapeutics; School of Veterinary Medicine; Centre for Biosecurity and One Health; School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.258 Zoonotic Diseases; 1.258.227 Tick-borne Pathogens
Web Of Science research areas: Parasitology
ESI research areas: Microbiology