Anaerobic metabolism of inspiratory muscles in COPD

Peter R. Eastwood; Tom J. Van Der TOUW; Gavin A. Sturdy; Sue C. Jenkins; David R. Hillman

doi:10.1111/j.1440-1843.2006.00781.x

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Anaerobic metabolism of inspiratory muscles in COPD

Journal article

Peer reviewed

Anaerobic metabolism of inspiratory muscles in COPD

Peter R. Eastwood, Tom J. Van Der TOUW, Gavin A. Sturdy, Sue C. Jenkins and David R. Hillman

Respirology (Carlton, Vic.), Vol.11(1), pp.32-40

Received 23 December 2004; invited to revise 6 July 2005; revised 22 July 2005; accepted 4 September 2005 (Associate Editor: Michiaki Mishima).

2006

DOI: https://doi.org/10.1111/j.1440-1843.2006.00781.x

PMID: 16423199

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Abstract

blood lactate concentration

COPD

inspiratory muscle training

inspiratory threshold load

inspiratory work rate

Objective The purpose of this study was to determine if the respiratory muscles of patients with COPD could be made to function anaerobically, as evidenced by an increase in arterial blood lactate concentration ([lactate]a) during specific loading of the inspiratory muscles and, if so, the effect of a programme of high-intensity inspiratory muscle training on this function. Methods In seven patients with COPD (FEV1 = 33 ± 14% of predicted), measurements of [lactate]a were made each minute during progressive inspiratory threshold loading to voluntary exhaustion. These tests were performed before and after an 8-week programme of specific high-intensity inspiratory muscle training, combined with general whole-body exercise training. Results During inspiratory muscle loading small increases in [lactate]a (0.83 ± 0.32 mM) were observed in two subjects before training, and in five subjects after training (0.69 ± 0.57 mM). [Lactate]a only increased when the inspiratory work rate exceeded 6.9 cm H2O L/min per kilogram of body weight, and when baseline maximum inspiratory pressure exceeded 65 cm H2O. Conclusions The results of this study demonstrated that it is possible for COPD patients to increase inspiratory muscle work rate to a level requiring a major energy contribution from anaerobic glycolytic metabolism. This was only seen when inspiratory muscle strength and endurance were sufficient to allow it. Some patients who failed to demonstrate an increase in [lactate]a at baseline did so after a programme of high-intensity inspiratory muscle training.

Details

Title: Anaerobic metabolism of inspiratory muscles in COPD
Authors/Creators: Peter R. Eastwood - The University of Western Australia
Tom J. Van Der TOUW - Departments of Pulmonary Physiology and
Gavin A. Sturdy - The University of Western Australia
Sue C. Jenkins - Sir Charles Gairdner Hospital
David R. Hillman - Departments of Pulmonary Physiology and
Publication Details: Respirology (Carlton, Vic.), Vol.11(1), pp.32-40
Publisher: Blackwell Science Pty
Edition: Received 23 December 2004; invited to revise 6 July 2005; revised 22 July 2005; accepted 4 September 2005 (Associate Editor: Michiaki Mishima).
Number of pages: 9
Identifiers: 991005592643307891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.192 COPD
Web Of Science research areas: Respiratory System
ESI research areas: Clinical Medicine