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Journal article
Characterization of novel calcium compounds from tilapia (Oreochromis niloticus) by-products and their effects on proliferation and differentiation of MC3T3-E1 cells
Journal of functional foods, Vol.100, 105361
2023
Abstract
This study aimed to produce and characterize of a powder mixture from tilapia (Oreochromis niloticus) bone resulting from the addition to hydroxyapatite (HA) of various acids (lactic acid, citric acid, and malic acid). Structured hydroxyapatite lactate compound (SHA-Lac) and SHA-citrate malate compound (SHA-CiMa) were water-soluble and Ca and P were the most abundant minerals contained in those compounds had main elements in Ca and P. FT-IR indicated that COOH played an important role for Ca2+ binding. XRD patterns indicated these compounds were amorphous crystal. For bioavailability on preosteoblast MC3T3-E1 cells, all samples at 100 μg/mL showed no cytotoxicity, no change in morphology, and no cell apoptosis, with the percentage of cell viability higher than 80%. For ability of mineral deposition at 7, 14, and 21 days of culture, all samples significantly increased the mineralization of MC3T3-E1osteoblast cells, thereby resulting in rising of the proliferation and differentiation during the early stages.
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Details
- Title
- Characterization of novel calcium compounds from tilapia (Oreochromis niloticus) by-products and their effects on proliferation and differentiation of MC3T3-E1 cells
- Authors/Creators
- Chakkapat Aenglong - Ocean University of ChinaNujamee Ngasakul - Kasetsart UniversityMaruj Limpawattana - Siam UniversityWanida Sukketsiri - Prince of Songkla UniversityDr Suwimol ChockchaisawasdeeCostas Stathopoulos - Murdoch University, Food Futures InstituteSupita Tanasawet - Prince of Songkla UniversityWanwimol Klaypradit - Kasetsart University
- Publication Details
- Journal of functional foods, Vol.100, 105361
- Publisher
- Elsevier Ltd; AMSTERDAM
- Number of pages
- 9
- Grant note
- Office of the Ministry of Higher Education, Science, Research and InnovationThailand Science Research and Innovation through the Kasetsart University Reinventing University ProgramEuropean Union's Horizon 2020 Research and Innovation Program: 952594
This work was financially supported by the Office of the Ministry of Higher Education, Science, Research and Innovation; and the Thailand Science Research and Innovation through the Kasetsart University Reinventing University Program 2021 and European Union's Horizon 2020 Research and Innovation Program [grant number 952594, ERA Chair project DRIFT-FOOD] .
- Identifiers
- 991005715570207891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Murdoch University; Food Futures Institute
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.165 Nanofibers, Scaffolds & Fabrication
- 2.165.163 Hydroxyapatite Composites
- Web Of Science research areas
- Food Science & Technology
- Nutrition & Dietetics
- ESI research areas
- Agricultural Sciences