Journal article
Childhood Sleep Behaviours and Polycystic Ovary Syndrome Risk in Adolescence: The Raine Study Cohort Longitudinal Study
The journal of clinical endocrinology and metabolism, Vol.111(8), dgag078
2026
PMID: 41742375
Abstract
Background
Sleep disturbances are common in women with polycystic ovary syndrome (PCOS), but no prospective studies have explored whether childhood–adolescence sleep disturbances are associated with later PCOS risk. Understanding behavioral markers may support early identification and intervention.
Objective
To examine whether poor sleep behaviors from childhood to adolescence are prospectively associated with a diagnosis of PCOS at age 14 years.
Materials and methods
Sleep behavior data (Child Behavior Checklist) from a longitudinal study of 226 female participants of the Raine Study cohort (37 with PCOS), assessed at ages 5, -8, -10, and -14 years, with PCOS diagnosis at age 14 years were analyzed. PCOS diagnosis was based on both hyperandrogenism and ovulatory dysfunction according to the 2023 PCOS Guideline adolescent diagnostic criteria. Generalized estimating equations examined longitudinal sleep behavior differences by PCOS status at age 14; logistic regression explored specific sleep behavior associations with PCOS risk at age 14.
Results
After adjustment for covariates, results showed higher sleep behavior problem scores from childhood to adolescence, with differences becoming more pronounced over time among girls with PCOS at age 14 (adjusted mean difference = 0.49; 95% CI = 0.10-0.87; P = .013). Analysis of individual items showed significant associations between PCOS at age 14 and “trouble sleeping” at age 10 (odds ratio [OR] = 2.95; 95% CI = 1.30-6.69) and “sleeping less than most kids” at age 10 (OR = 2.48; 95% CI = 1.18-5.22).
Conclusion
Sleep difficulties may serve as early, modifiable behavioral markers of PCOS risk. Poor sleep may worsen hormonal and metabolic dysfunction, promoting insulin resistance, obesity, and sleep disturbances.
Details
- Title
- Childhood Sleep Behaviours and Polycystic Ovary Syndrome Risk in Adolescence: The Raine Study Cohort Longitudinal Study
- Authors/Creators
- Nur K Abdul Jafar - Monash UniversityJoanne A McVeigh - Curtin UniversityPeter R Eastwood - Health Futures Institute, Murdoch University, Perth, AustraliaRoger J Hart - The University of Western Australia, Division of Obstetrics and Gynaecology, Faculty of Health and Medical Sciences, Perth, AustraliaParneet Sethi - Monash HealthAnju E Joham - Monash HealthChau Thien Tay - Monash HealthHelena J Teede - Monash HealthChristie J Bennett - Academy of Nutrition and DieteticsDarren R Mansfield - Monash HealthLisa J Moran - Monash Health
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.111(8), dgag078
- Publisher
- Oxford University Press on behalf of the Endocrine Society. ; WASHINGTON
- Number of pages
- 12
- Identifiers
- 991005870608107891
- Copyright
- © The Author(s) 2026.
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.81 Reproductive Biology
- 1.81.510 PCOS and Infertility
- Web Of Science research areas
- Endocrinology & Metabolism
- ESI research areas
- Clinical Medicine