Files and links (1)
Published (Version of Record)CC BY V4.0, Open Access
Journal article
Childhood sleep health and epigenetic age acceleration in late adolescence: Cross-sectional and longitudinal analyses
Acta Paediatrica, Vol.112(5), pp.1001-1010
2023
PMID: 36808764
Abstract
Aim
Investigate if childhood measures of sleep health are associated with epigenetic age acceleration in late adolescence.
Methods
Parent-reported sleep trajectories from age 5 to 17, self-reported sleep problems at age 17, and six measures of epigenetic age acceleration at age 17 were studied in 1192 young Australians from the Raine Study Gen2.
Results
There was no evidence for a relationship between the parent-reported sleep trajectories and epigenetic age acceleration (p ≥ 0.17). There was a positive cross-sectional relationship between self-reported sleep problem score and intrinsic epigenetic age acceleration at age 17 (b = 0.14, p = 0.04), which was attenuated after controlling for depressive symptom score at the same age (b = 0.08, p = 0.34). Follow-up analyses suggested this finding may represent greater overtiredness and intrinsic epigenetic age acceleration in adolescents with higher depressive symptoms.
Conclusion
There was no evidence for a relationship between self- or parent-reported sleep health and epigenetic age acceleration in late adolescence after adjusting for depressive symptoms. Mental health should be considered as a potential confounding variable in future research on sleep and epigenetic age acceleration, particularly if subjective measures of sleep are used.
Details
- Title
- Childhood sleep health and epigenetic age acceleration in late adolescence: Cross-sectional and longitudinal analyses
- Authors/Creators
- David Balfour - Flinders UniversityPhillip E. Melton - University of TasmaniaJoanne A. McVeigh - Curtin UniversityRae-Chi Huang - Edith Cowan University (Australia, Bunbury) - ECUPeter R. Eastwood - Adelaide Institute for Sleep HealthSian Wanstall - Adelaide Institute for Sleep HealthAmy C. Reynolds - Adelaide Institute for Sleep HealthSarah Cohen-Woods - Flinders University
- Publication Details
- Acta Paediatrica, Vol.112(5), pp.1001-1010
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- Flinders University National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia Raine Medical Research Foundation
- Identifiers
- 991005592644107891
- Copyright
- © 2023 The Authors
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
10 File views/ downloads
47 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.349 Insomnia
- Web Of Science research areas
- Pediatrics
- ESI research areas
- Clinical Medicine