Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence

Michelle Olaithe; Timothy C. Skinner; David Hillman; Peter E. Eastwood; Romola S. Bucks

doi:10.1007/s11325-014-1000-2

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Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence

Journal article

Peer reviewed

Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence

Michelle Olaithe, Timothy C. Skinner, David Hillman, Peter E. Eastwood and Romola S. Bucks

Sleep & breathing, Vol.19(1), pp.221-230

2015

DOI: https://doi.org/10.1007/s11325-014-1000-2

PMID: 24839237

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Abstract

OSA

AHI

Cognition

Neuropsychology

Structural Equation Modelling

Introduction Obstructive sleep apnea (OSA) is a common disorder that is associated with impaired attention, memory and executive function. However, the mechanisms underlying such dysfunction are unclear. To determine the influence of sleep fragmentation and hypoxia, this study examined the effect of sleep fragmentation and hypoxia on cognition in OSA, while controlling for potentially confounding variables including sleepiness, age and premorbid intelligence. Method Participants with and without OSA (N = 150) were recruited from the general community and a tertiary hospital sleep clinic. All underwent comprehensive, laboratory-based polysomnography (PSG) and completed assessments of cognition including attention, short- and long-term memory and executive function. Structural equation modelling (SEM) was used to construct a theoretically-driven model to examine the relationships between hypoxia and sleep fragmentation, and cognitive function. Results Although after controlling for IQ, increased sleep disturbance was a significant predictor of decreased attention (p = 0.04) and decreased executive function (p = 0.05), controlling for age removes these significant relationships. No significant predictors of memory function were found. Conclusions The mechanisms underlying the effects of OSA on cognition remain to be defined. Implications are discussed in light of these findings.

Details

Title: Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence
Authors/Creators: Michelle Olaithe - The University of Western Australia
Timothy C. Skinner - Charles Darwin University
David Hillman - West Australian Sleep Disorders Research Institute
Peter E. Eastwood - College Station Medical Center
Romola S. Bucks - The University of Western Australia
Publication Details: Sleep & breathing, Vol.19(1), pp.221-230
Publisher: Springer Nature
Number of pages: 10
Grant note: Philips Respironics
Identifiers: 991005592648007891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.137 Sleep Science & Circadian Systems; 1.137.382 Obstructive Sleep Apnea
Web Of Science research areas: Clinical Neurology; Respiratory System
ESI research areas: Neuroscience & Behavior