Journal article
Cognitive profiles in obstructive sleep apnea: a cluster analysis in sleep clinic and community samples
Journal of clinical sleep medicine, Vol.16(9), pp.1493-1505
2020
PMID: 32400387
Abstract
STUDY OBJECTIVES: Although cognitive dysfunction is a recognized consequence of untreated obstructive sleep apnea (OSA), the deficit pattern is heterogeneous. Understanding this heterogeneity may identify those at risk of cognitive deficits and guide intervention strategies. To facilitate understanding, we examined whether distinct profiles of neuropsychological performance were present in OSA and, if so, how they are related to other OSA features.
METHODS: We studied sleep clinic (n = 121) and community (n = 398) samples with moderate-severe OSA (apnea-hypopnea index ≥ 15 events/h). Attention and memory were assessed using the Cognitive Drug Research system. Sleep was assessed using polysomnography in the clinic sample and dual channel (flow, oximetry) portable monitoring in the community sample. Latent profile analysis was used to determine structure of cognitive clusters. Discriminant function analysis was used to examine associations between nocturnal and diurnal features of OSA and profile membership.
RESULTS: Both samples were best characterized by a 3-profile solution: (1) strong thinkers (performed well across most domains and showed greater cognitive reserve); (2) inattentive fast thinkers (strong processing speed but poor ability to maintain attention); and (3) accurate slow thinkers (strengths in maintaining attention but poor processing speed). Profile membership was associated with mean overnight oxygen saturation and cognitive reserve in the clinic sample and the presence of cardiovascular disease and/or diabetes in the community sample.
CONCLUSIONS: These findings help explain the diversity of outcomes in previous studies of cognitive dysfunction in OSA by demonstrating that individual differences in cognitive reserve, nocturnal oxygen saturation, and comorbidities affect how cognition is impacted by OSA.
Details
- Title
- Cognitive profiles in obstructive sleep apnea: a cluster analysis in sleep clinic and community samples
- Authors/Creators
- Michelle Olaithe - The University of Western AustraliaMaria Pushpanathan - The University of Western AustraliaDavid Hillman - The University of Western AustraliaPeter R. Eastwood - The University of Western AustraliaMichael Hunter - The University of Western AustraliaTimothy Skinner - University of CopenhagenAlan James - West Australian Sleep Disorders Research InstituteKeith A. Wesnes - Swinburne University of TechnologyRomola S. Bucks - The University of Western Australia
- Publication Details
- Journal of clinical sleep medicine, Vol.16(9), pp.1493-1505
- Publisher
- Amer Acad Sleep Medicine
- Number of pages
- 13
- Grant note
- Government of Western Australia (Office of Science, Department of Health) City of Busselton
- Identifiers
- 991005592647107891
- Copyright
- © 2020 American Academy of Sleep Medicine
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.382 Obstructive Sleep Apnea
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior