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Published (Version of Record)CC BY-NC-ND V4.0, Open Access
Journal article
Cross‐sectional interrelationships between chronotype, obstructive sleep apnea and blood pressure in a middle‐aged community cohort
Journal of sleep research, Vol.32(3), e13778
2023
PMID: 36330799
Abstract
Chronotype is linked to adverse health measures and may have important associations with obstructive sleep apnea and blood pressure, but data are limited. This study aimed to determine the separate and combined associations of chronotype with obstructive sleep apnea and blood pressure in a middle-aged community population. Adults (n = 811) from the Raine Study (female = 59.2%; age mean [range] = 56.6 [42.1–76.6] years) were assessed for chronotype (Morningness–Eveningness Questionnaire), blood pressure and hypertension (doctor diagnosed or systolic blood pressure ≥ 140 mmHg and/or diastolic ≥ 90 mmHg), and obstructive sleep apnea at different in-laboratory apnea–hypopnea index thresholds (5, 10, 15 events per hr). Linear and logistic regression models examined relationships between chronotype and the presence and severity of obstructive sleep apnea, blood pressure, hypertension, and blood pressure stratified by obstructive sleep apnea severity at above-mentioned apnea–hypopnea index thresholds. Covariates included age, sex, body mass index, alcohol consumption, smoking, physical activity, sleep duration, anti-hypertensive medication, insomnia, and depressive symptoms. Most participants were categorised as morning (40%) or intermediate (43%), with 17% meeting criteria for evening chronotypes. Participants with apnea–hypopnea index ≥ 15 events per hr and morning chronotype had higher systolic (9.9 mmHg, p < 0.001) and a trend for higher diastolic blood pressure (3.4 mmHg, p = 0.07) compared with those with an evening chronotype, and higher systolic blood pressure compared with those with an intermediate chronotype (4.8 mmHg, p = 0.03). Across chronotype categories, no differences in systolic or diastolic blood pressure or odds of hypertension were found at apnea–hypopnea index thresholds of ≥ 5 or ≥ 10 events per hr. Among participants with apnea–hypopnea index ≥ 15 events per hr, systolic blood pressure is higher in those with a morning chronotype than evening and intermediate chronotypes. Assessment for morning chronotype may improve risk stratification for hypertension in patients with obstructive sleep apnea.
Details
- Title
- Cross‐sectional interrelationships between chronotype, obstructive sleep apnea and blood pressure in a middle‐aged community cohort
- Authors/Creators
- Kelly Sansom - The University of Western AustraliaAmy Reynolds - Flinders UniversitySatvinder S. Dhaliwal - Singapore University of Social SciencesJennifer Walsh - The University of Western AustraliaKathleen Maddison - Sir Charles Gairdner HospitalBhajan Singh - Sir Charles Gairdner HospitalPeter Eastwood - Flinders UniversityNigel McArdle - Sir Charles Gairdner Hospital
- Publication Details
- Journal of sleep research, Vol.32(3), e13778
- Number of pages
- 12
- Grant note
- Women and Infants Research Foundation University of Notre Dame Australia University of Western Australia Murdoch University National Health and Medical Research Council Lions Eye Institute Telethon Kids Institute Edith Cowan University Curtin University Raine Medical Research Foundation
- Identifiers
- 991005592659107891
- Copyright
- © 2022 The Authors
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.349 Insomnia
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior