Journal article
Decoding dangerous death: how cytotoxic chemotherapy invokes inflammation, immunity or nothing at all
Cell Death and Differentiation, Vol.15(1), pp.13-20
2008
Abstract
Chemotherapy and immunotherapy can be either synergistic or antagonistic modalities in the treatment of cancer. Cytotoxic chemotherapy not only affects the tumor but also targets dividing lymphocytes, the very cells that are required to develop an immune response. For this reason, chemo- and immunotherapy have been seen as antagonistic. However, cell death can be immunogenic and the way in which chemotherapeutic drug kills a tumor cell is likely to be an important determinant of how that dying cell interacts with the immune system and whether the interaction will lead to an immune response. When a cell dies as the result of infection, the immune system responds rapidly and the system of Toll-like receptors (TLR) plays a key role in this process. In this review, we will briefly summarize the intracellular signaling pathways that link TLR ligation with immune activation and we will address the questions where and how TLRs recognize their targets.
Details
- Title
- Decoding dangerous death: how cytotoxic chemotherapy invokes inflammation, immunity or nothing at all
- Authors/Creators
- R.G. van der Most (Author/Creator)A.J. Currie (Author/Creator)B.W.S Robinson (Author/Creator)R.A. Lake (Author/Creator)
- Publication Details
- Cell Death and Differentiation, Vol.15(1), pp.13-20
- Publisher
- Nature Publishing Group
- Identifiers
- 991005543116107891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.214 Checkpoint Inhibition
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- ESI research areas
- Molecular Biology & Genetics