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Published (Version of Record)CC BY-NC V4.0, Open Access
Journal article
Early life predictors of obstructive sleep apnoea in young adults: Insights from a longitudinal community cohort (Raine study)
Sleep medicine, Vol.110, pp.76-81
2023
Abstract
Objective
Early-life obstructive sleep apnoea (OSA) predictors are unavailable for young adults. This study identifies early-life factors predisposing young adults to OSA.
Methods
This retrospective study included 923 young adults and their mothers from the Western Australian Pregnancy Raine Study Cohort. OSA at 22 years was determined from in-laboratory polysomnography. Logistic regression was used to identify maternal and neonatal factors associated with OSA in young adulthood.
Results
OSA was observed in 20.8% (192) participants. Maternal predictors of OSA included gestational diabetes mellitus (odds ratio (OR) 9.54, 95% confidence interval (CI) 1.7, 58.5, P = 0.011), preterm delivery (OR 3.18, 95%CI 1.1,10.5, P = 0.043), preeclampsia (OR 2.95, 95%CI 1.1,8.0, P = 0.034), premature rupture of membranes (OR 2.46, 95%CI 1.2, 5.2, P = 0.015), age ≥35 years (OR 2.28, 95%CI 1.2,4.4, P = 0.011), overweight and obesity (pregnancy BMI≥25 kg/m2) (OR 2.00, 95%CI 1.2,3.2, P = 0.004), pregnancy-induced hypertension (OR 1.89, 95%CI 1.1,3.2, P = 0.019), and Chinese ethnicity (OR 2.36,95%CI 1.01,5.5, P = 0.047). Neonatal predictors included male child (OR 2.10, 95%CI 1.5,3.0, P < 0.0001), presence of meconium-stained liquor during delivery (OR 1.60, 95%CI 1.0,2.5, P = 0.044) and admission to special care nursery (OR 1.51 95%CI 1.0,2.2, P = 0.040). Higher birth lengths reduced OSA odds by 7% for each centimetre (OR 0.93, 95%CI 0.87, 0.99, P = 0.033).
Conclusions
A range of maternal and neonatal factors predict OSA in young adults, including those related to poor maternal metabolic health, high-risk pregnancy and stressful perinatal events. This information could assist in the early identification and management of at-risk individuals and indicates that better maternal health may reduce the likelihood of young adults developing OSA.
Details
- Title
- Early life predictors of obstructive sleep apnoea in young adults: Insights from a longitudinal community cohort (Raine study)
- Authors/Creators
- Mon Ohn - The University of Western AustraliaNigel McArdle - The University of Western AustraliaR. Nazim Khan - The University of Western AustraliaBritta S. von Ungern-Sternberg - The Kids Research Institute AustraliaPeter R. Eastwood - Murdoch UniversityJennifer H. Walsh - The University of Western AustraliaAndrew C. Wilson - The Kids Research Institute AustraliaKathleen J. Maddison - The University of Western Australia
- Publication Details
- Sleep medicine, Vol.110, pp.76-81
- Publisher
- Elsevier B.V.
- Identifiers
- 991005594402707891
- Copyright
- © 2023 The Authors
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.382 Obstructive Sleep Apnea
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior