Effect of PolyGlycopleX (PGX) consumption on blood lipid profiles in healthy, Low CVD risk overweight adults

V.A. Solah; D.A. Kerr; D. Irawati; W. Hunt; X. Meng; R.J. Gahler; R.J. Fenton; H.K. Fenton; S.K. Johnson; A.P. James

doi:10.3390/nu11040717

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Effect of PolyGlycopleX (PGX) consumption on blood lipid profiles in healthy, Low CVD risk overweight adults

Journal article

Open access

Peer reviewed

Effect of PolyGlycopleX (PGX) consumption on blood lipid profiles in healthy, Low CVD risk overweight adults

V.A. Solah, D.A. Kerr, D. Irawati, W. Hunt, X. Meng, R.J. Gahler, R.J. Fenton, H.K. Fenton, S.K. Johnson and A.P. James

Nutrients, Vol.11(4), 717

2019

DOI: https://doi.org/10.3390/nu11040717

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Abstract

Raised blood lipid levels are associated with a risk of a cardiovascular disease (CVD). Moderate reductions in several CVD factors such as total, low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol concentrations may be more effective in reducing overall risk than a major reduction in just one. A blind, randomised controlled trial was conducted with 120 healthy overweight (BMI 25–30) adults aged 25–70 years who were non-smokers, not diabetic and of low risk of cardiovascular disease, as assessed by the Framingham risk equation. Participants consumed 4.5 g PolyGlycopleX (PGX) as softgel capsules (PGXS) or 5 g PGX granules (PGXG) or 5 g rice flour (RF) with meals three times a day for 12 weeks. Total, LDL and non-HDL cholesterol were all significantly reduced (−6%, −5% and −3.5%, respectively) post the PGX granule treatment; however, PGX in softgel capsule form did not affect blood lipid profiles. Daily consumption of PGX granules in overweight low CVD risk adults produced lipid changes indicating a CVD preventative benefit.

Details

Title: Effect of PolyGlycopleX (PGX) consumption on blood lipid profiles in healthy, Low CVD risk overweight adults
Authors/Creators: V.A. Solah (Author/Creator) - Curtin University
D.A. Kerr (Author/Creator) - Curtin University
D. Irawati (Author/Creator) - University of Mataram
W. Hunt (Author/Creator) - Curtin University
X. Meng (Author/Creator) - Flinders University
R.J. Gahler (Author/Creator) - Factors Group R & D, Burnaby, BC V3N4S9, Canada. rgahler@naturalfactors.com.
R.J. Fenton (Author/Creator)
H.K. Fenton (Author/Creator) - Curtin University
S.K. Johnson (Author/Creator) - Curtin University
A.P. James (Author/Creator) - Curtin University
Publication Details: Nutrients, Vol.11(4), 717
Publisher: MDPI
Identifiers: 991005544392007891
Copyright: © 2019 by the authors.
Murdoch Affiliation: Murdoch University; College of Environmental and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.85 Food Science & Technology; 3.85.99 Cereal Starch Properties
Web Of Science research areas: Nutrition & Dietetics
ESI research areas: Agricultural Sciences