Journal article
Effects on upper airway collapsibility of presence of a pharyngeal catheter
Journal of sleep research, Vol.24(1), pp.92-99
2015
PMID: 25131139
Abstract
Catheters that traverse the pharynx are often in place during clinical or research evaluations of upper airway function. The purpose of this study was to determine whether the presence of such catheters affects measures of upper airway collapsibility itself. To do so, pharyngeal critical closing pressure (Pcrit) and resistance upstream of the site of collapse Rus) were assessed in 24 propofol-anaesthetized subjects (14 men) with and without a multi-sensor oesophageal catheter (external diameter 2.7 mm) in place. Anaesthetic depth and posture were maintained constant throughout each study. Six subjects had polysomnography(PSG)-defined obstructive sleep apnea (OSA) and 18 either did not have or were at low risk of OSA. Airway patency was maintained with positive airway pressure. At intervals, pressure was reduced by varying amounts to induce varying degrees of inspiratory flow limitation. The slope of the pressure flow relationship for flow-limited breaths defined Rus. Pcrit was similar with the catheter in and out (−1.5 ± 5.4 cmH2O and −2.1 ± 5.6 cmH2O, respectively, P = 0.14, n = 24). This remained the case both for those with PSG-defined OSA (3.9 ± 2.2 cmH2O and 2.6 ± 1.4 cmH2O, n = 6) and those at low risk/without OSA (−3.3 ± 4.9 cmH2O and -3.7 ± 5.6 cmH2O, respectively, n = 18). Rus was similar with the catheter in and out (20.0 ± 12.3 cmH2O mL−1 s−1 and 16.8 ± 10.1 cmH2O mL−1 s−1, P = 0.22, n = 24). In conclusion, the presence of a small catheter traversing the pharynx had no significant effect on upper airway collapsibility in these anaesthestized subjects, providing reassurance that such measures can be made reliably in their presence.
Details
- Title
- Effects on upper airway collapsibility of presence of a pharyngeal catheter
- Authors/Creators
- Kathleen J. Maddison - Sir Charles Gairdner HospitalKelly L. Shepherd - Univ Western Australia, Sch Anat Physiol & Human Biol, Ctr Sleep Sci, Crawley, WA, AustraliaVanessa A. Baker - The University of Western AustraliaBradley Lawther - Sir Charles Gairdner HospitalPeter Platt - Sir Charles Gairdner HospitalDavid R. Hillman - The University of Western AustraliaPeter R. Eastwood - The University of Western AustraliaJennifer H. Walsh - The University of Western Australia
- Publication Details
- Journal of sleep research, Vol.24(1), pp.92-99
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- 572647 / NHMRC; National Health and Medical Research Council (NHMRC) of Australia 11027 / Australia and New Zealand College of Anaesthetists Australian Government 1042341 / NHMRC Senior Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia Safety Net Top-up Scholarship from The University of Western Australia
- Identifiers
- 991005592657407891
- Copyright
- © 2014 European Sleep Research Society
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- 1.137 Sleep Science & Circadian Systems
- 1.137.382 Obstructive Sleep Apnea
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