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Journal article
Exercise-induced responses in matrix metalloproteinases and osteopontin are not moderated by exercise format in males with overweight or obesity
European journal of applied physiology, Vol.123(5), pp.1115-1124
2023
PMID: 36648516
Appears in Open Access via Read & Publish Agreements
Abstract
Purpose
Matrix metalloproteinase-2 (MMP-2) and -3 (MMP-3), and osteopontin (OPN) are associated with adipose-tissue expansion and development of metabolic disease. The purpose of the current study was to assess the circulating concentration of these markers, along with adiponectin and glucose concentrations, in response to acute exercise in individuals with overweight or obesity.
Methods
Fourteen sedentary males with overweight or obesity (29.0 ± 3.1 kg/m2) completed two separate, 3-day trials in randomised and counterbalanced order. An oral glucose tolerance test (OGTT) was performed on each day of the trial. Day two of each trial consisted of a single 30 min workload-matched bout of either high-intensity interval exercise (HIIE; alternating 100% and 50% of peak pulmonary oxygen uptake, V.
O2peak) or continuous moderate intensity (CME; 60% V.
O2peak) cycling completed 1 h prior to the OGTT. Glucose and physical activity were continuously monitored, while MMP-2, MMP-3, OPN and adiponectin were measured pre-, 0 h post-, 1 h post- and 25 h post-exercise.
Results
Exercise transiently increased MMP-3 and decreased OPN (both p < 0.01), but not MMP-2 or adiponectin. There were no differences in the response of inflammatory markers to the different exercise formats. Exercise increased mean daily glucose concentration and area under the glucose curve during the OGTT on Day 2 and Day 3 (main effect of time; p < 0.05).
Conclusion
Acute cycling exercise decreased OPN, which is consistent with longer term improvements in cardiometabolic health and increased MMP-3, which is consistent with its role in tissue remodelling. Interestingly, exercise performed prior to the morning OGTT augmented the glucose concentrations in males.
Trial registration
ACTRN12613001086752.
Details
- Title
- Exercise-induced responses in matrix metalloproteinases and osteopontin are not moderated by exercise format in males with overweight or obesity
- Authors/Creators
- Aaron Raman - Discipline of Exercise Science, Murdoch UniversityJeremiah J. Peiffer - Murdoch University, Centre for Healthy AgeingGerard F. Hoyne - School of Health Sciences and Physiotherapy, Notre Dame UniversityNathan G. Lawler - Murdoch University, Health Futures InstituteAndrew Currie - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsTimothy J. Fairchild - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
- Publication Details
- European journal of applied physiology, Vol.123(5), pp.1115-1124
- Publisher
- Springer Berlin Heidelberg
- Identifiers
- 991005571669807891
- Copyright
- © 2023 The Author(s)
- Murdoch Affiliation
- Australian National Phenome Centre; Centre for Healthy Ageing; Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Web Of Science research areas
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