Journal article
Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea
Journal of sleep research, Vol.20(1), pp.241-249
2011
PMID: 20545839
Abstract
Repetitive airway occlusion during sleep in patients with obstructive sleep apnoea (OSA) results in the generation of negative intrathoracic pressures and ends in arousal, both of which may predispose to reflux during sleep (nocturnal reflux). We aimed to determine and compare the prevalence of nocturnal reflux symptoms and their sleep-associated risk factors in untreated OSA patients, OSA patients using continuous positive airway pressure (CPAP) therapy, and the general population. Gastro-oesophageal reflux and sleep questionnaires were completed by 1116 patients with polysomnography diagnosed OSA and by 1999 participants of the 2007 Busselton population health survey. Of the OSA patients, 137 completed the reflux questionnaire before and after treatment. Risk of OSA in the general population was assessed using the Berlin score. The prevalence of frequent (>weekly) nocturnal reflux symptoms was increased (P < 0.001) in OSA patients (10.2%) versus the general population (5.5%), in individuals from the general population at high (8.7%) versus low risk (4.3%) of OSA and in patients with severe (13.9%) versus mild OSA (5.1%). Frequent nocturnal reflux symptoms were associated with high risk (general population) (OR 1.9, P < 0.01) and severity of OSA (OSA population) OR 3.0, severe versus mild OSA, P < 0.001) after correcting for age, gender and body mass index. Treatment with CPAP decreased the prevalence of reflux symptoms significantly. In conclusion, the prevalence of nocturnal reflux symptoms is increased in those with or suspected of having OSA. This association is independent of other risk factors including age, gender and body mass index, suggesting a causal relationship between OSA and nocturnal reflux.
Details
- Title
- Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea
- Authors/Creators
- Kelly L. Shepherd - Sir Charles Gairdner Hosp, W Australian Sleep Disorders Res Inst, Dept Pulm Physiol, Nedlands, WA 6009, AustraliaAlan L. James - West Australian Sleep Disorders Research InstituteArthur W. Musk - Sir Charles Gairdner HospitalMichael L. Hunter - Sir Charles Gairdner HospitalDavid R. Hillman - West Australian Sleep Disorders Research InstitutePeter R. Eastwood - West Australian Sleep Disorders Research Institute
- Publication Details
- Journal of sleep research, Vol.20(1), pp.241-249
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- 513704; 513769; 557500; 353532 / NHMRC; National Health and Medical Research Council (NHMRC) of Australia Sir Charles Gairdner Hospital Research Foundation
- Identifiers
- 991005591575107891
- Copyright
- © 2010 European Sleep Research Society
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.95 Gastrointestinal & Esophageal Diseases
- 1.95.541 GERD & Achalasia
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior