Journal article
Heat treatment and irradiation reduce anti-bacterial and immune-modulatory properties of bovine colostrum
Journal of Functional Foods, Vol.57, pp.182-189
2019
Abstract
Colostrum contains bioactive components protecting the newborn intestine against bacteria. It is unclear how to optimize processing conditions with highest product bioactivity. Non-pasteurized (BC00), standard-pasteurized (72 °C-15 s, BC72), gently-pasteurized bovine colostrums without (63 °C-30 min, BC63) and with gamma-irradiation (BC63g) were tested for effects on bacterial growth inhibition (Escherichia coli, Staphylococcus aureus and S. epidermidis), intestinal epithelial cell (IEC) proliferation and cytokine secretion in vitro. Thermal processing decreased endogenous bacteria and IgG levels. All BCs inhibited bacterial growth 1–2 h after inoculation, but only BC00, BC63 and BC63g retained activity after 4–24 h. After 4 h, the activity against S. epidermidis of BC63g was lower than BC00 but still potent when mixed with formula. All BCs stimulated IEC proliferation, with the most pronounced responses for BC00. Only BC00 and BC63 increased IL-8 secretion in lipopolysaccharide-stimulated IECs. Thermal processing reduced bioactivity and combined gentle pasteurization and gamma-irradiation improved BC sterility and bioactivity, relative to standard pasteurization.
Details
- Title
- Heat treatment and irradiation reduce anti-bacterial and immune-modulatory properties of bovine colostrum
- Authors/Creators
- D.N. Nguyen (Author/Creator) - University of CopenhagenA.J. Currie (Author/Creator) - Murdoch UniversityS. Ren (Author/Creator) - University of CopenhagenS.B. Bering (Author/Creator) - University of CopenhagenP.T. Sangild (Author/Creator) - University of Copenhagen
- Publication Details
- Journal of Functional Foods, Vol.57, pp.182-189
- Publisher
- Elsevier Ltd.
- Identifiers
- 991005543749507891
- Copyright
- © 2019 Published by Elsevier Ltd.
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.891 Breastfeeding
- Web Of Science research areas
- Food Science & Technology
- Nutrition & Dietetics
- ESI research areas
- Agricultural Sciences