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Author’s VersionCC BY-NC-ND V4.0, Open Access
Journal article
Host stress physiology and Trypanosoma haemoparasite infection influence innate immunity in the woylie (Bettongia penicillata)
Comparative Immunology, Microbiology and Infectious Diseases, Vol.46, pp.32-39
2016
Abstract
Understanding immune function is critical to conserving wildlife in view of infectious disease threats, particularly in threatened species vulnerable to stress, immunocompromise and infection. However, few studies examine stress, immune function and infection in wildlife. We used a flow cytometry protocol developed for human infants to assess phagocytosis, a key component of innate immunity, in a critically endangered marsupial, the woylie (Bettongia penicillata). The effects of stress physiology and Trypanosoma infection on phagocytosis were investigated. Blood and faecal samples were collected from woylies in a captive facility over three months. Trypanosoma status was determined using PCR. Faecal cortisol metabolites (FCM) were quantified by enzyme-immunoassay. Mean phagocytosis measured was >90%. An interaction between sex and FCM influenced the percentage of phagocytosing leukocytes, possibly reflecting the influence of sex hormones and glucocorticoids. An interaction between Trypanosoma status and FCM influenced phagocytosis index, suggesting that stress physiology and infection status influence innate immunity.
Details
- Title
- Host stress physiology and Trypanosoma haemoparasite infection influence innate immunity in the woylie (Bettongia penicillata)
- Authors/Creators
- S. Hing (Author/Creator)A. Currie (Author/Creator)S. Broomfield (Author/Creator)S. Keatley (Author/Creator)K. Jones (Author/Creator)R.C.A. Thompson (Author/Creator)E. Narayan (Author/Creator)S.S. Godfrey (Author/Creator)
- Publication Details
- Comparative Immunology, Microbiology and Infectious Diseases, Vol.46, pp.32-39
- Publisher
- Elsevier BV
- Identifiers
- 991005544527407891
- Copyright
- © 2016 Published by Elsevier Ltd.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.261 Parasitology - Trypanosoma & Leishmania
- 1.261.596 Trypanosoma Biology
- Web Of Science research areas
- Immunology
- Microbiology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science