In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography

Julian J. Armstrong; Matthew S. Leigh; Ian D. Walton; Andrei V. Zvyagin; Sergey A. Alexandrov; Stefan Schwer; David D. Sampson; David R. Hillman; Peter R. Eastwood

doi:10.1364/OE.11.001817

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In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography

Journal article

Open access

Peer reviewed

In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography

Julian J. Armstrong, Matthew S. Leigh, Ian D. Walton, Andrei V. Zvyagin, Sergey A. Alexandrov, Stefan Schwer, David D. Sampson, David R. Hillman and Peter R. Eastwood

Optics express, Vol.11(15), pp.1817-1826

2003

DOI: https://doi.org/10.1364/OE.11.001817

PMID: 19466064

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Abstract

Optical coherence tomography

Endoscopic imaging

Medical and biological imaging

We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).

Details

Title: In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography
Authors/Creators: Julian J. Armstrong
Matthew S. Leigh
Ian D. Walton
Andrei V. Zvyagin
Sergey A. Alexandrov
Stefan Schwer
David D. Sampson
David R. Hillman
Peter R. Eastwood
Publication Details: Optics express, Vol.11(15), pp.1817-1826
Identifiers: 991005592766307891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 5 Physics; 5.250 Imaging & Tomography; 5.250.1350 Optical Coherence Tomography
Web Of Science research areas: Optics
ESI research areas: Physics