Journal article
Innate immunity in human newborn infants: prematurity means more than immaturity
Journal of Maternal-Fetal and Neonatal Medicine, Vol.24(1), pp.25-31
2011
Abstract
Neonates, particularly those born prematurely, are exquisitely vulnerable to life-threatening infections. This increased susceptibility to infection is maintained into childhood. Despite the considerable human and economic cost of infection-related neonatal morbidity and mortality, the mechanisms underlying this heightened susceptibility are only partly understood. It is increasingly recognised that innate immune responses are key to the protection against infection early in life, and emerging data suggest that such responses are deficient in the newborn and especially in preterm infants. Here we review the current understanding of the maturation of the innate immune response in human neonates highlighting the clinical relevance and possible avenues for therapeutic intervention.
Details
- Title
- Innate immunity in human newborn infants: prematurity means more than immaturity
- Authors/Creators
- T. Strunk (Author/Creator)A. Currie (Author/Creator)P. Richmond (Author/Creator)K. Simmer (Author/Creator)D. Burgner (Author/Creator)
- Publication Details
- Journal of Maternal-Fetal and Neonatal Medicine, Vol.24(1), pp.25-31
- Publisher
- Informa Healthcare
- Identifiers
- 991005545513007891
- Copyright
- © 2011 Informa UK, Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.1757 Group B Streptococcus
- Web Of Science research areas
- Obstetrics & Gynecology
- ESI research areas
- Clinical Medicine