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Published (Version of Record)CC BY-NC-ND V4.0, Open Access
Journal article
Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease
Neurobiology of sleep and circadian rhythms, Vol.6, pp.1-8
2019
PMCID: PMC6586591
PMID: 31236517
Abstract
Objective
Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington’s disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse. This study aimed to comprehensively evaluate the relationships between hypothalamic pathology and circadian rhythm and habitual sleep disturbances in individuals with premanifest HD.
Methods
Thirty-two individuals with premanifest HD and twenty-nine healthy age- and gender-matched controls participated in this dual-site, cross-sectional study. Magnetic resonance imaging scans were performed to evaluate hypothalamic volume. Circadian rhythm and habitual sleep were assessed via measurement of morning and evening cortisol and melatonin levels, wrist-worn actigraphy, the Consensus Sleep Diary and sleep questionnaires. Information on mood, physical activity levels and body composition were also collected.
Results
Compared to healthy controls, individuals with premanifest HD displayed significantly reduced grey matter volume in the hypothalamus, decreased habitual sleep efficiency and increased awakenings; however, no alterations in morning cortisol or evening melatonin release were noted in individuals with premanifest HD. While differences in the associations between hypothalamic volume and cortisol and melatonin output existed in individuals with premanifest HD compared to healthy controls, no consistent associations were observed between hypothalamic volume and circadian rhythm or habitual sleep outcomes.
Conclusion
While significant differences in associations between hypothalamic volume and cortisol and melatonin existed between individuals with premanifest HD and healthy controls, no differences in circadian markers were observed between the groups. This suggests that circadian regulation is maintained despite hypothalamic pathology, perhaps via neural compensation. Longitudinal studies are required to further understand the relationships between the hypothalamus and circadian rhythm and habitual sleep disturbances in HD as the disease course lengthens.
Details
- Title
- Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease
- Authors/Creators
- Danielle M. Bartlett - Edith Cowan UniversityJuan F. Domínguez D - School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia School of Psychology, Australian Catholic University, Melbourne, Victoria, Australia Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, Western Australia, Australia Exercise Medicine Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia Centre for Sleep Science, School of Human Sciences, Faculty of Science, University of Western Australia, Crawley, Western Australia, Australia Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, Norfolk, United Kingdom School of Biomedical Science, University of Western Australia, Crawley, Western Australia, Australia Peron Institute for Neurological and Translational Science, Perth, Western Australia, AustraliaAlvaro Reyes - Universidad Andrés BelloPauline Zaenker - Edith Cowan UniversityKirk W. Feindel - The University of Western AustraliaRobert U. Newton - Edith Cowan UniversityAnthony J. Hannan - Florey Institute of Neuroscience and Mental HealthJames A. Slater - School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia School of Psychology, Australian Catholic University, Melbourne, Victoria, Australia Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, Western Australia, Australia Exercise Medicine Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia Centre for Sleep Science, School of Human Sciences, Faculty of Science, University of Western Australia, Crawley, Western Australia, Australia Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, Norfolk, United Kingdom School of Biomedical Science, University of Western Australia, Crawley, Western Australia, Australia Peron Institute for Neurological and Translational Science, Perth, Western Australia, AustraliaPeter R. Eastwood - The University of Western AustraliaAlpar S. Lazar - University of East AngliaMel Ziman - School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia School of Psychology, Australian Catholic University, Melbourne, Victoria, Australia Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, Western Australia, Australia Exercise Medicine Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia Centre for Sleep Science, School of Human Sciences, Faculty of Science, University of Western Australia, Crawley, Western Australia, Australia Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, Norfolk, United Kingdom School of Biomedical Science, University of Western Australia, Crawley, Western Australia, Australia Peron Institute for Neurological and Translational Science, Perth, Western Australia, AustraliaTravis Cruickshank - Edith Cowan University
- Publication Details
- Neurobiology of sleep and circadian rhythms, Vol.6, pp.1-8
- Publisher
- Elsevier
- Identifiers
- 991005591572407891
- Copyright
- © 2018 The Authors
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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