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Open Access CC BY-NC-ND V4.0
Journal article
LOX-A4 shapes Triticum urartu gene pools and contributions to the A subgenome of polyploid wheat
Nature communications, Vol.17, 5511
2026
PMID: 42014395
Abstract
Lipoxygenases (LOXs) play vital roles in plant growth and defense. In this study, through genomic and molecular analyses, we discover a major LOX gene (LOX-A4) differentially expressed in Triticum urartu (Tu), the diploid progenitor of A subgenome in polyploid wheat. Compared to Tu accessions carrying wild type gene (LOX-A4W), those bearing mutant allele (LOX-A4m) show better growth but lower stress tolerance. These differences concur with a wider geographical distribution of LOX-A4m accessions than LOX-A4W materials in the Fertile Crescent. Interestingly, only mutant LOX-A4 alleles are detected in 3,516 worldwide tetraploid and hexaploid wheat lines; restoring LOX-A4W expression in common wheat inhibits growth but enhances stress tolerance. Furthermore, genome-wide identity-by-state analysis reveals that polyploid wheat A subgenome is more related to the A genome in 13 LOX-A4m Tu accessions. Thus, our work provides evidence that LOX gene variation shapes plant gene pools and their contributions to polyploid genome formation via regulating growth-defense trade-offs.
Details
- Title
- LOX-A4 shapes Triticum urartu gene pools and contributions to the A subgenome of polyploid wheat
- Authors/Creators
- Bei Li - National Engineering Research Center for WheatZhiyong Wang - The Shennong Laboratory, Zhengzhou, ChinaLingli Dong - State Key Laboratory of Plant GenomicsZhenying Dong - Hebei Agricultural UniversityKunpu Zhang - National Engineering Research Center for WheatYanpeng Wang - Institute of Genetics and Developmental BiologyReyazul Rouf Mir - Sher-e-Kashmir University of Agricultural Sciences and Technology of KashmirJinfang Chu - State Key Laboratory of Plant GenomicsYiwen Li - State Key Laboratory of Plant GenomicsMingtian Zhao - National Engineering Research Center for WheatMengen Chen - National Engineering Research Center for WheatZhaohui Wang - National Engineering Research Center for WheatYue Zhang - National Engineering Research Center for WheatLidan Guo - National Engineering Research Center for WheatAnnapurna Chitikineni - Murdoch UniversityJijun Yan - State Key Laboratory of Plant GenomicsPeiyong Xin - State Key Laboratory of Plant GenomicsBingbing Zhang - National Engineering Research Center for WheatJunlong Li - National Engineering Research Center for WheatXiao Sun - National Engineering Research Center for WheatYuxuan Meng - National Engineering Research Center for WheatYining Wang - The Shennong Laboratory, Zhengzhou, ChinaYanmeng Ding - National Engineering Research Center for WheatJiatian Wang - National Engineering Research Center for WheatShengjia Zhang - National Engineering Research Center for WheatCuilan Shi - National Engineering Research Center for WheatZehong Yan - Sichuan Agricultural UniversityShoufen Dai - Sichuan Agricultural UniversityWeining Song - Northwest A&F UniversityCaixia Gao - State Key Laboratory of Plant GenomicsRajeev K Varshney - Murdoch UniversityZhiyong Liu - State Key Laboratory of Plant GenomicsDaowen Wang - ZhengZhou Shengda University Of Economics, Business & ManagementGuangwei Li - National Engineering Research Center for Wheat
- Publication Details
- Nature communications, Vol.17, 5511
- Publisher
- Springer Nature
- Identifiers
- 991005878749007891
- Copyright
- © The Author(s) 2026.
- Murdoch Affiliation
- Food Futures Institute
- Language
- English
- Resource Type
- Journal article
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