Loss of antigen cross-presentation after complete tumor resection is associated with the generation of protective tumor-specific CD8+ T-cell immunity

M.D. Brown; R. van der Most; J.B. Vivian; R.A. Lake; I. Larma; B.W.S. Robinson; A.J. Currie

doi:10.4161/onci.20924

Back

Loss of antigen cross-presentation after complete tumor resection is associated with the generation of protective tumor-specific CD8+ T-cell immunity

Journal article

Open access

Peer reviewed

Loss of antigen cross-presentation after complete tumor resection is associated with the generation of protective tumor-specific CD8+ T-cell immunity

M.D. Brown, R. van der Most, J.B. Vivian, R.A. Lake, I. Larma, B.W.S. Robinson and A.J. Currie

OncoImmunology, Vol.1(7), pp.1084-1094

2012

DOI: https://doi.org/10.4161/onci.20924

Files and links (2)

pdf

loss_of_antigen_cross-presentation.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

An incomplete understanding on the effect of surgery on tumor-specific immunity continues to hamper efforts to combine surgery with immunotherapy in the clinic. Herein, we describe the impact of tumor resection on the tumor-specific T-cell response, showing that complete tumor resection is associated with (1) a decline in the amount of cross-presented tumor antigens, (2) a decline of cytolytic tumor-specific CD8+ T cell activity, and (3) the development of systemic CD8+ T cell-mediated protective immunity. Our findings are consistent with a model whereby tumor resection releases antitumor CD8+ T cells from chronic antigen exposure, allowing a gradual differentiation toward functional antitumor memory T cells. This process depends on sentinel lymph nodes, as their removal at the time of surgery was associated with a strong negative effect on survival. We conclude that complete tumor resection provides a unique environment that boosts protective immunological memory and might provide a powerful platform for immunotherapy. Our findings also carry important implications for the design and timing of post-surgery immunotherapeutic regimens.

Details

Title: Loss of antigen cross-presentation after complete tumor resection is associated with the generation of protective tumor-specific CD8+ T-cell immunity
Authors/Creators: M.D. Brown (Author/Creator) - Sir Charles Gairdner Hospital
R. van der Most (Author/Creator) - GSK Biologicals; Rixensart, Belgium
J.B. Vivian (Author/Creator) - The University of Western Australia
R.A. Lake (Author/Creator) - The University of Western Australia
I. Larma (Author/Creator) - Sir Charles Gairdner Hospital
B.W.S. Robinson (Author/Creator) - The University of Western Australia
A.J. Currie (Author/Creator) - National Research Centre for Asbestos Related Diseases; University of Western Australia; Perth, Australia; School of Veterinary and Biomedical Sciences; Murdoch University; Perth, Australia
Publication Details: OncoImmunology, Vol.1(7), pp.1084-1094
Publisher: Landes Bioscience
Identifiers: 991005544680907891
Copyright: © 2012 Landes Bioscience
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

811 File views/ downloads

50 Record Views

20 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.358 Dendritic Cell Therapy
Web Of Science research areas: Immunology; Oncology
ESI research areas: Biology & Biochemistry