Journal article
Maternal chorioamnionitis and postneonatal respiratory tract infection in ex-Preterm infants
The Journal of Pediatrics, Vol.184, pp.62-67
2017
Abstract
Objective: To assess whether exposure to histologically confirmed chorioamnionitis (ie, histologic chorioamnionitis [HCA]) is associated with altered risk of infection-related hospitalization (IRH) during the first 24 months of life in very preterm infants. Study design: This single-center retrospective cohort study analyzed data on 1218 infants born at <30 weeks gestational age (GA). Semiquantitative placental histology, obstetric, and neonatal data were extracted from hospital databases and linked with discharge diagnoses on rehospitalization until age 24 months from statewide statutory data. The associations between HCA and overall and clinical categories of IRH were analyzed by Cox proportional hazards regression with left-truncated failure times. Results: Mean GA was 27 weeks, and HCA was present in 577 placentas (47.4%). Among the 1088 infants surviving until the birth-related discharge, 684 (62.9%) of had at least 1 IRH by age 24 months, of whom 287 included a diagnosis of acute lower respiratory tract infection (ALRTI). Following adjustment for sex, birth weight z-score, GA, early-onset sepsis, late-onset sepsis, previous antibiotic use, age at birth-related discharge, and chronic lung disease, HCA was associated with a 32% increased risk of hospitalization with ALRTI (HR, 1.32; 95% CI, 1.02-1.70; P = .033). There was no association with infection overall or with other infection categories. Conclusions: HCA is associated with a significantly increased risk of hospitalization with ALRTI that is independent of known risk factors, including chronic lung disease.
Details
- Title
- Maternal chorioamnionitis and postneonatal respiratory tract infection in ex-Preterm infants
- Authors/Creators
- D.P. Burgner (Author/Creator) - Murdoch Children's Research InstituteD. Doherty (Author/Creator) - Women and Infants Research FoundationJ. Humphreys (Author/Creator) - Women and Infants Research FoundationA. Currie (Author/Creator) - The University of Western AustraliaK. Simmer (Author/Creator) - King Edward Memorial HospitalA. Charles (Author/Creator) - Sidra Medical and Research CenterT. Strunk (Author/Creator) - The University of Western Australia
- Publication Details
- The Journal of Pediatrics, Vol.184, pp.62-67
- Publisher
- Elsevier
- Identifiers
- 991005540170207891
- Copyright
- © 2017 Elsevier Inc.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.924 Preterm Birth Causes
- Web Of Science research areas
- Pediatrics
- ESI research areas
- Clinical Medicine