Journal article
Methamphetamine exposure during pregnancy: A meta-analysis of child developmental outcomes
Neuroscience & Biobehavioral Reviews, Vol.138, Art. 104714
2022
Abstract
This paper examines developmental outcomes for children prenatally exposed to methamphetamine through maternal use. PSYCHINFO, Scopus, PubMed and ERIC databases were systematically searched for studies up to December 2020. The search identified 38 articles examining cognitive, language, motor and neuroanatomical outcomes in children from birth to 16 years. Study quality was appraised using the Newcastle Ottawa Quality Assessment Scale. Findings from neuroanatomical studies suggested that prenatal methamphetamine exposure may alter whole brain microstructure and reduce subcortical volumes across multiple brain regions. Meta-analysis of 14 studies using a random-effects model revealed associations between exposure and poorer intellectual functioning (Cohen’s d = 0.89, 95 % CI: 0.47–1.30), problem solving skills (Cohen’s d = 0.82, 95 % CI: 0.07 −1.56), short-term memory (Cohen’s d = 0.91, 95 % CI: 0.38–1.43), and language development (Cohen’s d = 0.74, 95 % CI: 0.30–1.18). These results emphasise the significant impact of intrauterine methamphetamine exposure across multiple areas of child development, noting that limited total sample size, heterogeneity between studies and control for confounds suggested further studies are required. There is a need for further intervention studies to identify effective prevention and harm minimisation approaches.
Details
- Title
- Methamphetamine exposure during pregnancy: A meta-analysis of child developmental outcomes
- Authors/Creators
- C. Kunkler (Author/Creator) - Murdoch UniversityA.J. Lewis (Author/Creator) - Harry Perkins Institute of Medical ResearchR. Almeida (Author/Creator) - Murdoch University
- Publication Details
- Neuroscience & Biobehavioral Reviews, Vol.138, Art. 104714
- Publisher
- Elsevier
- Identifiers
- 991005541440707891
- Copyright
- © 2022 Elsevier Ltd.
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.100 Substance Abuse
- 1.100.1284 Prenatal Substance Exposure
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior