Modeling the upper airway: A precursor to personalized surgical interventions for the treatment of sleep apnea

Lachlan Hingley; Ali Jeiranikhameneh; Stephen Beirne; Gregory Peoples; Andrew Jones; Sepidar Sayyar; Peter Eastwood; Richard Lewis; Gordon Wallace; Stuart G. MacKay

doi:10.1002/jbm.a.36913

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Modeling the upper airway: A precursor to personalized surgical interventions for the treatment of sleep apnea

Journal article

Peer reviewed

Modeling the upper airway: A precursor to personalized surgical interventions for the treatment of sleep apnea

Lachlan Hingley, Ali Jeiranikhameneh, Stephen Beirne, Gregory Peoples, Andrew Jones, Sepidar Sayyar, Peter Eastwood, Richard Lewis, Gordon Wallace and Stuart G. MacKay

Journal of biomedical materials research. Part A, Vol.108(6), pp.1419-1425

2020

DOI: https://doi.org/10.1002/jbm.a.36913

PMID: 32134556

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Abstract

An accurate benchtop model was developed to mimic the different forms of human upper airway collapse in adult sleep apnea patients. This was done via modeling the airway through digital imaging. Airway representative models were then produced in two steps via a customized pneumatic extrusion 3D printing system. This allowed the pressure of collapse and planes of collapse to be manipulated to accurately represent those seen in sleep apnea patients. The pressure flow relationships of the collapsible airways were then studied by inserting the collapsible airways into a module that allowed the chamber pressure (Pc) around the airways to be increased in order to cause collapse. Airways collapsed at physiologically relevant pressures (5.32–9.58 cmH2O). Nickel and iron magnetic polymers were then printed into the airway in order to investigate the altering of the airway collapse. The introduction of the nickel and iron magnetic polymers increased the pressure of collapse substantially (7.38–17.51 cmH2O). Finally, the force produced by the interaction of the magnetic polymer and the magnetic module was studied by measuring a sample of the magnetic airways. The peak force in (48.59–163.34 cN) and the distance over which the forces initially registered (6.8–9.7 mm) were measured using a force transducer. This data set may be used to inform future treatment of sleep apnea, specifically the production of an implantable polymer for surgical intervention.

Details

Title: Modeling the upper airway: A precursor to personalized surgical interventions for the treatment of sleep apnea
Authors/Creators: Lachlan Hingley - University of Wollongong
Ali Jeiranikhameneh - University of Wollongong
Stephen Beirne - University of Wollongong
Gregory Peoples - University of Wollongong
Andrew Jones - University of Wollongong
Sepidar Sayyar - University of Wollongong
Peter Eastwood - The University of Western Australia
Richard Lewis - Royal Perth Hospital
Gordon Wallace - University of Wollongong
Stuart G. MacKay - University of Wollongong
Publication Details: Journal of biomedical materials research. Part A, Vol.108(6), pp.1419-1425
Publisher: Wiley
Number of pages: 7
Grant note: 2016-2018 / Garnett Passe and Rodney Williams Memorial Foundation
Identifiers: 991005592764607891
Copyright: © 2020 Wiley Periodicals, Inc.
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.137 Sleep Science & Circadian Systems; 1.137.382 Obstructive Sleep Apnea
Web Of Science research areas: Engineering, Biomedical; Materials Science, Biomaterials
ESI research areas: Materials Science