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Modulation of upper and lower esophageal sphincter tone during sleep
Journal article   Peer reviewed

Modulation of upper and lower esophageal sphincter tone during sleep

Peter R. Eastwood, Sawako Katagiri, Kelly L. Shepherd and David R. Hillman
Sleep medicine, Vol.8(2), pp.135-143
2007
DOI: https://doi.org/10.1016/j.sleep.2006.08.016
PMID: 17275400
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Abstract

Expiration Inspiration Lower esophageal sphincter Respiration Sleep Upper esophageal sphincter
Background and purpose The pressures generated within the upper esophageal sphincter (PUES) and lower esophageal sphincter (PLES) reflect the integrity of these barriers to gastroesophageal and pharyngoesophageal reflux, respectively. This study sought to describe the effects of sleep, respiration and posture on the function of the UES and the LES and the pressure differentials developed across them. Methods Ten healthy volunteers (7M, 3F: 38 ± 10 yr) without a history of sleep-disordered breathing or reflux underwent overnight polysomnography with simultaneous measurement of PLES and PUES using a purpose-built sleeve device (Dentsleeve). Posture was recorded but not controlled. Results Subjects slept for 4.3 ± 1.6 h. Compared to waking values, both end-inspiratory and end-expiratory Pues were significantly less during slow wave sleep (SWS) (p < 0.05). However, PLES was unaffected by sleep stage. During wakefulness and all stages of sleep, both PUES and PLES were greater at end-inspiration than end-expiration (p < 0.05). Similar relationships were observed whether subjects were supine or in the lateral decubitus position. Conclusion Sleep decreases the effectiveness of the UES to act as a barrier to pharyngoesophageal reflux, particularly during slow wave sleep (SWS). UES pressure varies with respiration, with minimal values observed during expiration. Hence, barrier function of the UES appears most impaired during SWS, in the expiratory phase of the respiratory cycle. The LES pressure and its barrier pressure also vary with respiration, being least during expiration. However, unlike the UES, the function of the LES was unaffected by sleep.

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Source: InCites

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14 Record Views
26 Times Cited - Web of Science

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.95 Gastrointestinal & Esophageal Diseases
1.95.541 GERD & Achalasia
Web Of Science research areas
Clinical Neurology
ESI research areas
Neuroscience & Behavior
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