Journal article
Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study
Journal of the neurological sciences, Vol.408, pp.116522-116522
2020
PMID: 31665619
Abstract
Background
Hypothalamic pathology is a well-documented feature of Huntington's disease (HD) and is believed to contribute to circadian rhythm and habitual sleep disturbances. Currently, no therapies exist to combat hypothalamic changes, nor circadian rhythm and habitual sleep disturbances in HD.
Objective
To evaluate the effects of multidisciplinary rehabilitation on hypothalamic volume, brain-derived neurotrophic factor (BDNF), circadian rhythm and habitual sleep in individuals with preclinical HD.
Methods
Eighteen individuals with HD (ten premanifest and eight prodromal) undertook a nine-month multidisciplinary rehabilitation intervention (intervention group), which included exercise, cognitive and dual task training and social events, and were compared to a community sample of eleven individuals with premanifest HD receiving no intervention (control group). Hypothalamic volume, serum BDNF, salivary cortisol and melatonin concentrations, subjective sleep quality, daytime somnolence, habitual sleep-wake patterns, stress and anxiety and depression symptomatology were evaluated.
Results
Hypothalamus grey matter volume loss was significantly attenuated in the intervention group compared to the control group after controlling for age, gender, Unified Huntington's Disease Rating Scale-Total Motor Score and number of cytosine-adenine-guanine repeats. Serum BDNF levels were maintained in the intervention group, but decreased in the control group following the study period. Both groups exhibited decreases in cortisol and melatonin concentrations. No changes were observed in sleep or mood outcomes.
Conclusions
This exploratory study provides evidence that multidisciplinary rehabilitation can reduce hypothalamic volume loss and maintain peripheral BDNF levels in individuals with preclinical HD but may not impact on circadian rhythm. Larger, randomised controlled trials are required to confirm these findings.
Details
- Title
- Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study
- Authors/Creators
- Danielle M. Bartlett - Edith Cowan UniversityJuan F. D. Dominguez - Australian Catholic UniversityAlpar S. Lazar - University of East AngliaCatarina C. Kordsachia - Monash UniversityTim J. Rankin - Edith Cowan UniversityJohnny Lo - Edith Cowan UniversityAndrew D. Govus - La Trobe UniversityBrian D. Power - The University of Notre Dame AustraliaAmit Lampit - The University of MelbournePeter R. Eastwood - The University of Western AustraliaMel R. Ziman - Edith Cowan Univ, Sch Med & Hlth Sci, 270 Joondalup Dr, Joondalup, WA, AustraliaTravis M. Cruickshank - Edith Cowan University
- Publication Details
- Journal of the neurological sciences, Vol.408, pp.116522-116522
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- 207799/Z/17/Z / Wellcome trust; Wellcome Trust; European Commission 107/20090827 / Lotterywest grant 1136548 / NHMRC Senior Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia
- Identifiers
- 991005591573407891
- Copyright
- © 2019 Elsevier B.V
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.951 Huntington's and Ataxias
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior