Musculoskeletal pain is associated with restless legs syndrome in young adults

Stijn J Hoogwout; Markus V Paananen; Anne J Smith; Darren J Beales; Peter B O'Sullivan; Leon M Straker; Peter R Eastwood; Nigel McArdle; David Champion

doi:10.1186/s12891-015-0765-1

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Musculoskeletal pain is associated with restless legs syndrome in young adults

Journal article

Open access

Peer reviewed

Musculoskeletal pain is associated with restless legs syndrome in young adults

Stijn J Hoogwout, Markus V Paananen, Anne J Smith, Darren J Beales, Peter B O'Sullivan, Leon M Straker, Peter R Eastwood, Nigel McArdle and David Champion

BMC musculoskeletal disorders, Vol.16(1), pp.294-294

2015

DOI: https://doi.org/10.1186/s12891-015-0765-1

PMCID: PMC4607251

PMID: 26467305

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Abstract

Musculoskeletal pain

Restless legs syndrome

Sleep disorders

Background In recent years, there is considerable evidence of a relationship between the sensorimotor disorder restless legs syndrome (RLS) and pain disorders, including migraine and fibromyalgia. An association between multi-site pain and RLS has been reported in adult women. In the current study, we explored the association between musculoskeletal (MSK) pain and RLS in a large cohort of young adults. Methods Twenty two year olds (n = 1072), followed since birth of part of the Western Australian Pregnancy Cohort (Raine) Study, provided data on MSK pain (duration, severity, frequency, number of pain sites). RLS was considered present when 4 diagnostic criteria recommended by the International Restless Legs Syndrome Study Group were met (urge to move, dysaesthesia, relief by movement, worsening symptoms during the evening/night) and participants had these symptoms at least 5 times per month. Associations between MSK pain and RLS were analyzed by multivariable logistic regression with bias-corrected bootstrapped confidence intervals, with final models adjusted for sex, psychological distress and sleep quality. Results The prevalence of RLS was 3.0 % and MSK pain was reported by 37.4 % of the participants. In multivariable logistic regression models, strong associations were found between RLS-diagnosis and long duration (three months or more) of MSK pain (odds ratio 3.6, 95 % confidence interval 1.4–9.2) and reporting three or more pain sites (4.9, 1.6–14.6). Conclusions Different dimensions of MSK pain were associated with RLS in young adults, suggestive of shared pathophysiological mechanisms. Overlap between these conditions requires more clinical and research attention.

Details

Title: Musculoskeletal pain is associated with restless legs syndrome in young adults
Authors/Creators: Stijn J Hoogwout - University Medical Center Groningen
Markus V Paananen - Oulu University Hospital
Anne J Smith - Curtin University
Darren J Beales - Curtin University
Peter B O'Sullivan - Curtin University
Leon M Straker - Curtin University
Peter R Eastwood - The University of Western Australia
Nigel McArdle - The University of Western Australia
David Champion - Sydney Children's Hospital
Publication Details: BMC musculoskeletal disorders, Vol.16(1), pp.294-294
Identifiers: 991005591572607891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.137 Sleep Science & Circadian Systems; 1.137.2136 Restless Legs Syndrome
Web Of Science research areas: Orthopedics; Rheumatology
ESI research areas: Clinical Medicine