Files and links (1)
CC BY-NC-ND V4.0, Open Access
Journal article
NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts
Journal of proteome research, Vol.24(8), pp.4191-4201
2025
PMID: 40700744
Abstract
Understanding the distribution and variation in NMR-based inflammatory markers is crucial to the evaluation of their clinical utility in disease prognosis and diagnosis. We applied high-resolution 1H NMR spectroscopy of blood plasma and serum to measure the acute phase reactive glycoprotein signals (GlycA and GlycB) and the subregions of the lipoprotein-based Supramolecular Phospholipid Composite signals (SPC1, SPC2, and SPC3) in a large multicohort population study. A total of 5702 samples were studied to determine the signal variations in a range of chronic and acute inflammatory conditions. We found that while GlycA and GlycB were increased in inflammation, the SPC regions behaved independently of Glyc signals, with SPC2 and SPC3 being reduced in chronic inflammation in comparison to healthy controls (p-value SPC2 = 2.9 × 10–10, p-value SPC3 = 2.2 × 10–3) and SPC1 (p-value = 0.29) being unchanged. SPC1 was decreased in acute inflammation, indicating a link to the immune response (p-value = 2.5 × 10–11). These findings confirm the independent biological relevance of all three SPC subregions and contraindicate the use of aggregate SPC values as general inflammatory markers.
Details
- Title
- NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts
- Authors/Creators
- Samantha Lodge - Murdoch University, Centre for Computational and Systems MedicineReika Masuda - Murdoch UniversityPhilipp Nitschke - Murdoch UniversityJohn P Beilby - The University of Western AustraliaJennie Hui - Pathwest Laboratory MedicineMichael Hunter - The University of Western AustraliaEdward Litton - Fiona Stanley HospitalEdward Raby - Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, WA6150, AustraliaAndrew Currie - Murdoch University, Personalised Medicine CentreBu B Yeap - Fiona Stanley HospitalOscar Millet - Euskadiko Parke TeknologikoaClaire Cannet - BrukerHartmut Schaefer - BrukerManfred Spraul - BrukerElaine Holmes - University of LondonJulien Wist - Murdoch University, Centre for Computational and Systems MedicineJeremy K Nicholson - Murdoch University, Health Futures Institute
- Publication Details
- Journal of proteome research, Vol.24(8), pp.4191-4201
- Publisher
- American Chemical Society.; WASHINGTON
- Number of pages
- 11
- Identifiers
- 991005796271007891
- Copyright
- © 2025 The Authors.
- Murdoch Affiliation
- Australian National Phenome Centre; School of Medical, Molecular and Forensic Sciences; Health Futures Institute; Personalised Medicine Centre; Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
38 File views/ downloads
12 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.211 Mass Spectrometry
- 2.211.990 Metabolomics
- Web Of Science research areas
- Biochemical Research Methods
- ESI research areas
- Biology & Biochemistry