Journal article
Neonatal immune responses to coagulase-negative staphylococci
Current Opinion in Infectious Diseases, Vol.20(4), pp.370-375
2007
Abstract
PURPOSE OF REVIEW: Coagulase-negative staphylococci have emerged as the most common nosocomial pathogen in neonatal intensive care units worldwide. Our understanding of the interactions between coagulase-negative staphylococci and the immune system is incomplete, especially in the newborn. This review summarizes current knowledge on the human immune response to coagulase-negative staphylococci, with particular emphasis on the neonatal innate immune system. RECENT FINDINGS: There are very limited data on innate immune responses to coagulase-negative staphylococci in neonates. Levels of serum proteins, including transplacental anti-coagulase-negative staphylococci immunoglobulin and complement, correlate with gestational age, and this relative deficiency in preterm infants contributes to their suboptimal opsonization and impaired bacterial killing of coagulase-negative staphylococci. In adults, coagulase-negative staphylococci elicit significant cytokine responses in vitro, which are probably partly mediated by Toll-like receptors, including Toll-like receptor type 2, but these pathways have not been characterized in the high-risk neonatal population. SUMMARY: The susceptibility of human preterm neonates to coagulase-negative staphylococci relates partly to the immaturity of the neonatal immune response. Strategies to reduce the burden of coagulase-negative staphylococci infections require a thorough understanding of host-pathogen interactions, particularly the engagement of coagulase-negative staphylococci by the neonatal innate immune system.
Details
- Title
- Neonatal immune responses to coagulase-negative staphylococci
- Authors/Creators
- T. Strunk (Author/Creator) - The University of Western AustraliaP. Richmond (Author/Creator) - School of Paediatrics and Child HealthK. Simmer (Author/Creator) - School of Paediatrics and Child HealthA. Currie (Author/Creator)O. Levy (Author/Creator)D. Burgner (Author/Creator) - School of Paediatrics and Child Health
- Publication Details
- Current Opinion in Infectious Diseases, Vol.20(4), pp.370-375
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005542976607891
- Copyright
- © 2007 Lippincott Williams & Wilkins, Inc
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.1757 Group B Streptococcus
- Web Of Science research areas
- Infectious Diseases
- ESI research areas
- Immunology