Journal article
Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care
The European respiratory journal, Vol.59(6), p.2101788
2022
PMID: 34824053
Abstract
Recent advances in obstructive sleep apnoea (OSA) pathophysiology and translational research have opened new lines of investigation for OSA treatment and management. Key goals of such investigations are to provide efficacious, alternative treatment and management pathways that are better tailored to individual risk profiles to move beyond the traditional continuous positive airway pressure (CPAP)-focused, “one size fits all” trial-and-error approach, which is too frequently inadequate for many patients. Identification of different clinical manifestations of OSA (clinical phenotypes) and underlying pathophysiological phenotypes (endotypes) that contribute to OSA have provided novel insights into underlying mechanisms and have underpinned these efforts. Indeed, this new knowledge has provided the framework for precision medicine for OSA to improve treatment success rates with existing non-CPAP therapies such as mandibular advancement devices and upper airway surgery, and newly developed therapies such as hypoglossal nerve stimulation and emerging therapies such as pharmacotherapies and combination therapy. Additionally, these concepts have provided insight into potential physiological barriers to CPAP adherence for certain patients. This review summarises the recent advances in OSA pathogenesis, non-CPAP treatment, clinical management approaches and highlights knowledge gaps for future research. OSA endotyping and clinical phenotyping, risk stratification and personalised treatment allocation approaches are rapidly evolving and will further benefit from the support of recent advances in e-health and artificial intelligence.
Details
- Title
- Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care
- Authors/Creators
- Jean-Louis Pépin - Université Grenoble AlpesPeter Eastwood - Adelaide Institute for Sleep HealthDanny J Eckert - Adelaide Institute for Sleep Health
- Publication Details
- The European respiratory journal, Vol.59(6), p.2101788
- Identifiers
- 991005592657307891
- Copyright
- © The Authors 2022
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.382 Obstructive Sleep Apnea
- Web Of Science research areas
- Respiratory System
- ESI research areas
- Clinical Medicine