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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Nucleic acid-based theranostics for tackling Alzheimer's Disease
Theranostics, Vol.7(16), pp.3933-3947
2017
Abstract
Nucleic acid-based technologies have received significant interest in recent years as novel theranostic strategies for various diseases. The approval by the United States Food and Drug Administration ( FDA) of Nusinersen, an antisense oligonucleotide drug, for the treatment of spinal muscular dystrophy highlights the potential of nucleic acids to treat neurological diseases, including Alzheimer's disease (AD). AD is a devastating neurodegenerative disease characterized by progressive impairment of cognitive function and behavior. It is the most common form of dementia; it affects more than 20% of people over 65 years of age and leads to death 7-15 years after diagnosis. Intervention with novel agents addressing the underlying molecular causes is critical. Here we provide a comprehensive review on recent developments in nucleic acid-based theranostic strategies to diagnose and treat AD.
Details
- Title
- Nucleic acid-based theranostics for tackling Alzheimer's Disease
- Authors/Creators
- M. Chakravarthy (Author/Creator) - Murdoch UniversityS. Chen (Author/Creator) - Murdoch UniversityP.R. Dodd (Author/Creator) - The University of QueenslandR.N. Veedu (Author/Creator) - Murdoch University
- Publication Details
- Theranostics, Vol.7(16), pp.3933-3947
- Publisher
- Ivyspring International Publisher
- Identifiers
- 991005540265107891
- Murdoch Affiliation
- Centre for Comparative Genomics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.57 Alzheimer's Mechanisms
- Web Of Science research areas
- Medicine, Research & Experimental
- ESI research areas
- Clinical Medicine