Journal article
Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients
Respirology (Carlton, Vic.), Vol.13(7), pp.1045-1052
2008
PMID: 18699804
Abstract
Background and objective: Gastroesophageal reflux (GOR) has been implicated in the pathogenesis of bronchiolitis obliterans syndrome (BOS), possibly due to pulmonary aspiration of refluxed acid. Risk of aspiration of gastric contents is increased during sleep due to decreased oesophageal clearance mechanisms and may be further increased by the presence of OSA. This study investigated the relationship between nocturnal GOR, OSA and BOS in a group of lung transplant patients.
Methods: Fourteen lung transplant patients underwent overnight polysomnography with simultaneous dual oesophageal pH monitoring.
Results: Patients had an FEV1 of 84 ± 15% of their best post-transplant FEV1. Six of the 14 patients were in various stages of BOS. The average proportion of time spent overnight with a pH of <4 was 1.7 ± 3.1%. Increased GOR was evident in 8/14 patients during the postprandial period and/or overnight in the distal and/or proximal oesophagus. All patients had OSA (AHI >5 events per hour). There were no relationships between severity of OSA or GOR and severity of BOS.
Conclusion: Both nocturnal GOR and OSA were common in this group of patients but their occurrences were not related. Neither was there any relationship between the presence of nocturnal GOR or OSA and severity of BOS.
Details
- Title
- Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients
- Authors/Creators
- Kelly L Shepherd - West Australian Sleep Disorders Research InstituteDaniel C Chambers - Royal Perth HospitalEli Gabbay - Royal Perth HospitalDavid R Hillman - West Australian Sleep Disorders Research InstitutePeter R Eastwood - The University of Western Australia
- Publication Details
- Respirology (Carlton, Vic.), Vol.13(7), pp.1045-1052
- Identifiers
- 991005591575307891
- Copyright
- © 2008 The Authors
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.95 Gastrointestinal & Esophageal Diseases
- 1.95.541 GERD & Achalasia
- Web Of Science research areas
- Respiratory System
- ESI research areas
- Clinical Medicine